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FMK 9a

Cat. No. 7496 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent ATG4B/autophagin-1 inhibitor; also inhibits calpain and cathepsin B
化学名： N-[(1S)-2-[(3-Fluoro-2-oxopropyl)amino]-2-oxo-1-(phenylmethyl)ethyl]-1-naphthalenecarboxamide
纯度： ≥90% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for FMK 9a

FMK 9a is a potent ATG4B/autophagin-1 inhibitor (IC50 values are 73 nM and 80 nM in cell-based LRA and TR-FRET assays, respectively). Also inhibits calpain and cathepsin B (IC50 values are 96 nM and 200 nM, respectively).

技术数据 for FMK 9a

分子量 392.43
公式 C23H21FN2O3
储存 Store at -20°C
纯度 ≥90% (HPLC)
CAS Number 1955550-51-2
PubChem ID 127020966
InChI Key VMVOHHPQIAPYHG-NRFANRHFSA-N
Smiles FCC(CNC([C@@H](NC(C1=CC=CC2=C1C=CC=C2)=O)CC3=CC=CC=C3)=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for FMK 9a

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.24 100

制备储备液 for FMK 9a

以下数据基于产品分子量 392.43。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.74 mL 25.48 mL
5 mM 0.51 mL 2.55 mL 5.1 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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参考文献 for FMK 9a

参考文献是支持产品生物活性的出版物。

Qiu et al (2016) Discovery of fluoromethylketone-based peptidomimetics as covalent ATG4B (autophagin-1) inhibitors. ACS Med.Chem.Lett. 7 802 PMID: 27563406

If you know of a relevant reference for FMK 9a, please let us know.

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关键词: FMK 9a, FMK 9a supplier, FMK9a, autophagin, autophagin-1, ATG4B, inhibitor, inhibitors, potent, calpain, cathepsin, B, Other, Proteases, Calpains, Cathepsin, 7496, Tocris Bioscience

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