主页 / 药理学 / GPCRs / 7-TM Receptors / Orphan 7-TM Receptors / Orphan 7-TM Receptor Agonists / FTBMT

FTBMT

Cat. No. 6784 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective GPR52 agonist; orally bioavailable and BBB permeable
别名： TP-024
化学名： 4-[3-[[3-Fluoro-5-(trifluoromethyl)phenyl]methyl]-5-methyl-1H-1,2,4-triazol-1-yl]-2-methylbenzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for FTBMT

FTBMT (also known as TP 024) is a potent and selective GPR52 agonist (EC50 = 75 nM, Emax = 122%), which is selective for GPR52 over a panel of 98 targets including D1, D2, AMPA and NMDA. FTBMT suppresses methamphetamine-induced hyperlocomotion in mice, and inhibits MK-801-induced hyperactivity (model for acute psychosis), without causing catalepsy in mice. This compound is orally bioavailable and brain penetrant.

External Portal Information for FTBMT

Chemicalprobes.org and the Chemical Probes webpages of the Structural Genomics Consortium are portals that offer independent guidance on the selection and/or application of small molecules for research. The use of FTBMT (TP 024) is reviewed on chemicalprobes.org and the SGC website.

化合物库 for FTBMT

FTBMT is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for FTBMT

分子量 392.35
公式 C19H16F4N4O
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1358575-02-6
PubChem ID 56649300
InChI Key TYXSIXOYTBHZFA-UHFFFAOYSA-N
Smiles CC1=NC(CC2=CC(C(F)(F)F)=CC(F)=C2)=NN1C3=CC(C)=C(C(N)=O)C=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for FTBMT

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.23 100
ethanol 19.62 50

制备储备液 for FTBMT

以下数据基于产品分子量 392.35。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.74 mL 25.49 mL
5 mM 0.51 mL 2.55 mL 5.1 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

产品说明书 for FTBMT

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for FTBMT

参考文献是支持产品生物活性的出版物。

Tokumaru et al (2017) Design, synthesis, and pharmacological evaluation of 4-azolyl-benzamide derivatives as novel GPR52 agonists. Bioorg.Med.Chem. 25 3098 PMID: 28433511

Nishiyama et al (2017) FTBMT, a novel and selective GPR52 agonist, demonstrates antipsychotic-like and procognitive effects in rodents, revealing a potential therapeutic agent for schizophrenia. J.Pharmacol.Exp.Ther. 363 253 PMID: 28851764

If you know of a relevant reference for FTBMT, please let us know.

按标靶查看相关产品

按产品操作查看相关产品

查看全部 Orphan 7-TM Receptor Agonists

关键词: FTBMT, FTBMT supplier, GPR52, agonist, agonism, potent, selective, Schizophrenia, psychosis, orally, bioavailable, and, BBB, permeable, TP-024, Orphan, 7-TM, Receptors, 6784, Tocris Bioscience

篇 FTBMT 的引用文献

引用文献是使用了 Tocris 产品的出版物。

目前没有 FTBMT 的引用文献。 您是否知道使用了 Tocris FTBMT 的优秀论文？ 请告知我们.

FTBMT 的评论

目前没有该产品的评论。 Be the first to review FTBMT and earn rewards!

Have you used FTBMT?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review