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Submit ReviewFTI 277
说明： Prodrug form of FTI 276 (Cat. No. 2406)
化学名： N-[4-[2(R)-Amino-3-mercaptopropyl]amino-2-phenylbenzoyl]methionine methyl ester trifluoroacetate salt
纯度： ≥95% (HPLC)
生物活性 for FTI 277
FTI 277 is a prodrug form of FTI 276 (Cat. No. 2406) that inhibits farnesyltransferase (FTase) (IC50 = 0.5 nM). Inhibits H-Ras and K-Ras processing in whole cells (IC50 values are 0.1 and 10 μM respectively) and disrupts constitutive H-Ras-specific activation of MAPK. Causes significant antiproliferative effects in human malignant glioma cells and many other tumor cell lines.
技术数据 for FTI 277
| 分子量 | 561.64 |
| 公式 | C22H29N3O3S2.C2HF3O2 |
| 储存 | Store at -80°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 1217447-06-7 |
| PubChem ID | 71311821 |
| InChI Key | GJEFFRDWFVSCOJ-PXPMWPIZSA-N |
| Smiles | SC[C@H](N)CNC1=CC=C(C(N[C@H]([C@@](OC)=O)CCSC)=O)C(C2=CC=CC=C2)=C1.FC(F)(C(O)=O)F |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for FTI 277
参考文献 for FTI 277
参考文献是支持产品生物活性的出版物。
Lerner et al (1995) Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling inducing cytoplasic accumulation of inactive Ras-Raf complexes. J.Biol.Chem. 270 26802 PMID: 7592920
Sun et al (1999) Antitumour efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, Tax. and gemcit. Cancer Res. 59 4919 PMID: 10519405
Lerner et al (1995) Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. J.Biol.Chem. 10 26770
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关键词: FTI 277, FTI 277 supplier, Prodrug, FTI, 276, 2406, farnesyltransferase, FTase, H-Ras, K-Ras, MAPK, anti-proliferative, antiproliferative, tumour, tumor, FTI277, Protein, Prenyltransferases, Post-translational, Modifications, 2407, Tocris Bioscience
1 篇 FTI 277 的引用文献
引用文献是使用了 Tocris 产品的出版物。 FTI 277 的部分引用包括：
Luttman et al (2021) ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells. Cell Rep. 37 109880 PMID: 34706244
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