Furosemide

Cat. No. 3109 6 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Na⁺/2Cl^-/K⁺ (NKCC) symporter inhibitor; also GABA_A antagonist

化学名： 5-(Aminosulfonyl)-4-chloro-2-([2-furanylmethyl]amino)benzoic acid

纯度： ≥99% (HPLC)

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Furosemide

Furosemide is a loop diuretic that inhibits the Na⁺/2Cl^-/K⁺ (NKCC) symporter. Also acts as a non-competitive antagonist at GABA_A receptors with ~ 100-fold greater selectivity for α6-containing receptors than α1-containing receptors.

化合物库 for Furosemide

Furosemide is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。

技术数据 for Furosemide

分子量	330.74
公式	C₁₂H₁₁ClN₂O₅S
储存	Store at RT
纯度	≥99% (HPLC)
CAS Number	54-31-9
PubChem ID	3440
InChI Key	ZZUFCTLCJUWOSV-UHFFFAOYSA-N
Smiles	ClC1=CC(NCC2=CC=CO2)=C(C(O)=O)C=C1S(=O)(N)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Furosemide

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	33.07	100

制备储备液 for Furosemide

以下数据基于产品分子量 330.74。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.02 mL	15.12 mL	30.24 mL
5 mM	0.6 mL	3.02 mL	6.05 mL
10 mM	0.3 mL	1.51 mL	3.02 mL
50 mM	0.06 mL	0.3 mL	0.6 mL

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产品说明书 for Furosemide

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Furosemide

参考文献是支持产品生物活性的出版物。

Thompson et al (1999) Residues in transmembrane domains I and II determine γ-aminobutyric acid type AA receptor subtype-selective antagonism by Furos.. Mol.Pharmacol. 55 993 PMID: 10347239

Gutschmidt et al (1999) Anticonvulsant actions of Furos. in vitro. Neuroscience 91 1471 PMID: 10391452

If you know of a relevant reference for Furosemide, please let us know.

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关键词: Furosemide, Furosemide supplier, Na+/2Cl-/K+, NKCC1, NKCC2, cotransporters, inhibitors, inhibits, antagonizes, GABAA, receptor, antagonists, blockers, Sodium, Potassium, Chloride, Ion, Transporters, Pumps, Receptors, diuretics, Na+/K+/Cl-, Symporter, 3109, Tocris Bioscience