G-36

Cat. No. 4759 3 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective GPER antagonist

化学名： (±)-(3aR*,4S*,9bS*)-4-(6-Bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-8-(1-methylethyl)-3H-cyclopenta[c]quinoline

纯度： ≥99% (HPLC)

引用文献 (3)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for G-36

G-36 is an antagonist of GPER; selectively inhibits estrogen-mediated activation of PI3-K by GPER, but not by ERα. Also inhibits estrogen-mediated calcium mobilization (IC₅₀ = 112 nM). Structural analog of G-1 (Cat. No. 3577).

化合物库 for G-36

G-36 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for G-36

分子量	412.33
公式	C₂₂H₂₂BrNO₂
储存	Store at -20°C
纯度	≥99% (HPLC)
CAS Number	1392487-51-2
PubChem ID	73755224
InChI Key	QTOCPACSSHFGOY-ZCCHDVMBSA-N
Smiles	BrC1=CC4=C(OCO4)C=[C@@]1[C@@H]2NC(C=CC(C(C)C)=C5)=C5[C@@]3([H])[C@@]([H])2CC=C3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for G-36

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	41.23	100

制备储备液 for G-36

以下数据基于产品分子量 412.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.43 mL	12.13 mL	24.25 mL
5 mM	0.49 mL	2.43 mL	4.85 mL
10 mM	0.24 mL	1.21 mL	2.43 mL
50 mM	0.05 mL	0.24 mL	0.49 mL

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产品说明书 for G-36

分析证书/产品说明书

化学品安全技术说明书

参考文献 for G-36

参考文献是支持产品生物活性的出版物。

Prossnitz and Barton (2011) The G-protein-coupled estrogen receptor GPER in health and disease. Nat.Rev.Endocrinol. 7 715 PMID: 21844907

Dennis et al (2011) Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity. J.Steroid Biochem.Mol.Biol. 127 358 PMID: 21782022

If you know of a relevant reference for G-36, please let us know.

按标靶查看相关产品

Estrogen (GPER) Receptors

关键词: G-36, G-36 supplier, G36, G-protein-coupled, estrogen, receptors, GPER, GPR30, antagonists, selective, Estrogen, (GPER), Receptors, 4759, Tocris Bioscience

3 篇 G-36 的引用文献

引用文献是使用了 Tocris 产品的出版物。 G-36 的部分引用包括：

Meseke et al (2018) Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin. Eneuro 5 PMID: 30406178

Bin et al (2020) G-protein-coupled estrogen receptor activation upregulates interleukin-1 receptor antagonist in the hippocampus after global cerebral ischemia: implications for neuronal self-defense. J Neuroinflammation 17 45 PMID: 32007102

Jing et al (2023) Anti-Inflammatory Actions of G-Protein-Coupled Estrogen Receptor 1 (GPER) and Brain-Derived Estrogen Following Cerebral Ischemia in Ovariectomized Rats. Biology (Basel) 12 PMID: 36671793

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Pathways for G-36

Estrogen Signaling Pathway

Estrogen is a steroid hormone that is responsible for the regulation of growth, differentiation and function of the reproductive system. Estrogen signaling is often dysregulated in breast cancer and osteoporosis.