Gabexate mesylate

Cat. No. 1798 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Serine protease inhibitor; inhibits thrombin, trypsin, kallikrein and plasmin

别名： FOY

化学名： 4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxy]-benzoic acid ethyl ester mesylate

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Gabexate mesylate

Gabexate mesylate is a serine protease inhibitor; Gabexate mesylate inhibits trypsin, plasmin, plasma kallikrein and thrombin (IC₅₀ values are 9.4, 30, 41 and 110 μM respectively). Antithrombotic in vitro and in vivo. Gabexate mesylate also inhibits LPS-induced TNF-α production, probably by inhibiting NF-κB and AP-1 activation. Gabexate mesylate attenuates allergen-induced airway inflammation and eosinophils infiltration in the lung of asthma murine model.

技术数据 for Gabexate mesylate

分子量	417.48
公式	C₁₆H₂₃N₃O₄.CH₃SO₃H
储存	Desiccate at RT
纯度	≥98% (HPLC)
CAS Number	56974-61-9
PubChem ID	6604915
InChI Key	ICDMLAQPOAVWNH-HAAQQRBASA-N
Smiles	CS(O)(=O)=O.CCOC(=O)C1=CC=C(OC(=O)CCCCCNC(N)=N)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Gabexate mesylate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	water	41.75	100

制备储备液 for Gabexate mesylate

以下数据基于产品分子量 417.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.4 mL	11.98 mL	23.95 mL
5 mM	0.48 mL	2.4 mL	4.79 mL
10 mM	0.24 mL	1.2 mL	2.4 mL
50 mM	0.05 mL	0.24 mL	0.48 mL

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产品说明书 for Gabexate mesylate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Gabexate mesylate

参考文献是支持产品生物活性的出版物。

et al (1981) FOY: [Ethyl Thromb.Res. 445 et al (2003) Gabexate mesilate, J.Pharmacol.Exp.Ther. 298 Ohno p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. I. Inhibition of thrombin and factor Xa in vitro. 19 PMID: 6449757

ght">Ohno p-(6-guanidinohexanoyloxy) benzoate] methanesulfonate as a serine proteinase inhibitor. II. In vivo effect on coagulo-fibrinolytic system in comparison with he. or apro. 24 PMID: 6178174

ght">Tamura inhibitors of trypsin, plasmin, kallikrein, thrombin, C_1r and C₁ esterase. 484 PMID: 143965

ght">Yuksel a synthetic protease inhibitor, inhibits lipopolysaccharide-induced tumor necrosis factor-α production by inhibiting activation of both nuclear factor-κB and activator protein-1 in human monocytes. 305 PMID: 12649382

ght">Chen inhibitors nafamostat mesilate and gabexate mesilate attenuate allergen induced airway inflammation and eosinophilia in a murine model of asthma. 118 PMID: 16815145 you know of a relevant reference for Gabexate mesylate, please let us know.

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