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Submit ReviewGatifloxacin
说明： Antibiotic; inhibits bacterial type II topoisomerase
别名： AM 1155
化学名： 1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid
纯度： ≥98% (HPLC)
生物活性 for Gatifloxacin
Fluoroquinolone antibiotic. Inhibits bacterial type II topoisomerases (IC50 values are 0.109 and 13.8 μg/ml for E.coli DNA gyrase and S.aureus topoisomerase IV respectively). Displays potent activity against gram-positive and gram-negative bacteria. Stimulates short-term self-renewal in both human and mouse embryonic stem cells in vitro.
技术数据 for Gatifloxacin
| 分子量 | 375.39 |
| 公式 | C19H22FN3O4 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 112811-59-3 |
| PubChem ID | 5379 |
| InChI Key | XUBOMFCQGDBHNK-UHFFFAOYSA-N |
| Smiles | O=C2C(C(O)=O)=CN(C3CC3)C1=C(OC)C(N4CC(C)NCC4)=C(F)C=C12 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Gatifloxacin
参考文献 for Gatifloxacin
参考文献是支持产品生物活性的出版物。
Takei et al (1998) Inhibitory activities of gatiflo. (AM-1155), a newly developed fluoroquinolone, against bacterial and mammalian type II topoisomerases. Antimicrob.Agents Chemother. 42 2678 PMID: 9756776
Desbordes et al (2008) High throughput screening assay for the identification of compounds regulating self-renewal and differentiation in human embryonic stem cells. Cell Stem Cell 2 602 PMID: 18522853
Fukuda et al (1998) Antibacterial activity of gatiflo. (AM-1155, CG5501, BMS-206584), a newly developed fluoroquinolone, against sequentially acquired quinolone-resistant mutants and the norA transformant of Staphylococcus aureus. Antimicrob.Agents Chemother. 42 1917 PMID: 9687384
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Gatifloxacin 的评论
平均评分: 5 (Based on 1 Review.)
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Gatifloxacin was used to understand its resistance pattern against S. aureus.
By
Anonymous on 02/09/2019
种属： Human
Gatifloxacin was used to understand its resistance pattern against S. aureus. E. coli strains were grown in Luria-Bertani medium, and S. aureus strains were grown in brain heart infusion medium for resistance study.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Cell Cycle and DNA Damage Research Product Guide
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Huntington's Disease Research Product Guide
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
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