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GI 530159

Cat. No. 6689 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： K2P2.1 (TREK-1) and K2P10.1 (TREK-2) channel activator
化学名： 4,4'-[[2,2,2-Trifluoro-1-(trifluoromethyl)ethylidene]bis(4,1-phenyleneoxy)]bis[benzenamine]
纯度： ≥99% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GI 530159

GI 530159 is a TREK1 and TREK2 channel activator (EC50 = 0.76 μM in Rb efflux assay in TREK1-expressing CHO cells). Exhibits selectivity for TREK1/2 over TRAAK, TASK3 and a range of other potassium channels. Hyperpolarizes membrane potential of dorsal root ganglion neurons and depresses neuronal activity in vitro.

化合物库 for GI 530159

GI 530159 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for GI 530159

分子量 518.45
公式 C27H20F6N2O2
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 69563-88-8
PubChem ID 94652
InChI Key HHLMWQDRYZAENA-UHFFFAOYSA-N
Smiles NC1=CC=C(C=C1)OC2=CC=C(C(C(F)(F)F)(C(F)(F)F)C3=CC=C(C=C3)OC4=CC=C(C=C4)N)C=C2

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GI 530159

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 51.84 100
ethanol 25.92 50

制备储备液 for GI 530159

以下数据基于产品分子量 518.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.93 mL 9.64 mL 19.29 mL
5 mM 0.39 mL 1.93 mL 3.86 mL
10 mM 0.19 mL 0.96 mL 1.93 mL
50 mM 0.04 mL 0.19 mL 0.39 mL

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参考文献 for GI 530159

参考文献是支持产品生物活性的出版物。

Loucif et al (2018) GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P) channel opener, reduces rat dorsal root ganglion neuron excitability. Br.J.Pharmacol. 175 2272 PMID: 29150838

If you know of a relevant reference for GI 530159, please let us know.

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关键词: GI 530159, GI 530159 supplier, GI530159, TREK1, TREK2, channel, activators, activates, K2P2, K2P10, Two-P, Potassium, Channels, 6689, Tocris Bioscience

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