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Ginkgolide B

Cat. No. 1657 1 次引用 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

1657 has been discontinued.

View all Platelet-Activating Factor (PAF) Receptors products.
说明： PAF receptor antagonist
别名： BN 52021
化学名： (1R,3S,3aS,4R,6aR,7aR,7bR,8S,10aS,11R,11aR)-3-(1,1-Dimethylethyl)hexahydro-4,7b,11-trihydroxy-8-methyl-9H-1,7a-(epoxymethano)-1H,6aH-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-5,9,12(4H)-trione
说明书
引用文献 (1)
评论
生物活性 技术数据 说明书 参考文献

生物活性 for Ginkgolide B

Ginkgolide B is a platelet-activating factor (PAF) receptor antagonist (Ki = 1.3 μM). Inhibits neutrophil degranulation and superoxide production in vitro and inhibits bronchoconstriction and is neuroprotective following oral administration in vivo.

技术数据 for Ginkgolide B

分子量 424.4
公式 C20H24O10
储存 Desiccate at +4°C
CAS Number 15291-77-7
PubChem ID 10971931
InChI Key SQOJOAFXDQDRGF-OTJOYSMWSA-N
Smiles O=C1[C@@H](C)[C@@]2(O)[C@@]([C@H](O)C34[C@]52O[C@@]6([H])[C@]([C@@H](O)C(O6)=O)3[C@H]([C@](C)(C)C)C[C@H]4O[C@]5=O)([H])O1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Ginkgolide B

参考文献是支持产品生物活性的出版物。

Desquand et al (1986) Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig. Eur.J.Pharmacol. 127 83 PMID: 3019727

Foldes-Filep et al (1987) Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes. Biochem.Biophys.Res.Commun. 148 1412 PMID: 2825685

Maclennan et al (2002) The CNS effects of Ginkgo biloba extracts and ginkgolide B. Prog.Neurobiol. 67 235 PMID: 12169298

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关键词: Ginkgolide B, Ginkgolide B supplier, PAF, receptor, antagonists, Receptors, Platelet-activating, Factor, GinkgolideB, BN52021, BN, 52021, (PAF), 1657, Tocris Bioscience

1 篇 Ginkgolide B 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Ginkgolide B 的部分引用包括：

Huang et al (2015) Protective effect of high concentration of BN52021 on retinal contusion in cat eyes. Nat Neurosci 15 50 PMID: 25956877

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