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Glimepiride

Cat. No. 2396 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

2396 has been discontinued.

View all Inward Rectifier Potassium (K<sub>ir</sub>) Channels products.
说明： Kir6 (KATP) channel blocker
别名： Amaryl,Glimperide
化学名： 3-Ethyl-2,5-dihydro-4-methyl-N-[2-[4-[[[[(trans-4-methylcyclohexyl)amino]carbonyl]amino]sulfonyl]phenyl]ethyl]-2-oxo-1H-pyrrole-1-carboxamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Glimepiride

Glimepiride is a potent Kir6 (KATP) channel blocker and anti-diabetic agent. Inhibits pinacidil-activated cardiac Kir6 channels with an IC50 of 6.8 nM.

技术数据 for Glimepiride

分子量 490.62
公式 C24H34N4O5S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 93479-97-1
PubChem ID 3476
InChI Key WIGIZIANZCJQQY-UHFFFAOYSA-N
Smiles O=C1C(CC)=C(C)CN1C(NCCC2=CC=C(S(NC(N[C@H]3CC[C@H](C)CC3)=O)(=O)=O)C=C2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Glimepiride

参考文献是支持产品生物活性的出版物。

Lawrence et al (2002) Effect of metabolic inhibition on glimep. block of native and cloned cardiac sacrolemmal KATP channels. Br.J.Pharmacol. 136 746 PMID: 12086984

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关键词: Glimepiride, Glimepiride supplier, KATP, channels, openers, Potassium, KIR, Inward, Rectifier, K+, Kir6, Amaryl, Glimperide, rectifier, Channels, 2396, Tocris Bioscience

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Glimepiride was used to evaluate the role of BK channel modulation on insulin secretion.
By Anonymous on 11/28/2018
分析类型： In Vitro
种属： Human

In pancreatic beta cells,ATP dependent potassium channels regulate glucose-dependent insulin secretion and serve as the target for sulfonylurea drugs used to treat type 2 diabetes.To understand the role of BK channels on insulin secretion,Glimepiride was used.

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