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GLPG 0974

Cat. No. 5621 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent FFA2 (GPR43) antagonist
化学名： 4-[[[(2R)-1-(Benzo[b]thien-3-ylcarbonyl)-2-methyl-2-azetidinyl]carbonyl][(3-chlorophenyl)methyl]amino]butanoic acid
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GLPG 0974

GLPG 0974 is a potent FFA2 antagonist (IC50 = 9 nM). Exhibits selectivity for FFA2 over FFA3. Inhibits acetate-induced human neutrophil migration in plasma or buffer. Also inhibits FFA2-induced expression of CD11b activation-specific epitope (AE) in human whole blood. Orally bioavailable.

化合物库 for GLPG 0974

GLPG 0974 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for GLPG 0974

分子量 485
公式 C25H25ClN2O4S
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 1391076-61-1
PubChem ID 57520598
InChI Key MPMKMQHJHDHPBE-RUZDIDTESA-N
Smiles O=C(N1[C@](C(N(CC2=CC(Cl)=CC=C2)CCCC(O)=O)=O)(C)CC1)C3=CSC4=C3C=CC=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GLPG 0974

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 48.5 100
ethanol 48.5 100

制备储备液 for GLPG 0974

以下数据基于产品分子量 485。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.06 mL 10.31 mL 20.62 mL
5 mM 0.41 mL 2.06 mL 4.12 mL
10 mM 0.21 mL 1.03 mL 2.06 mL
50 mM 0.04 mL 0.21 mL 0.41 mL

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产品说明书 for GLPG 0974

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for GLPG 0974

参考文献是支持产品生物活性的出版物。

Pizzonero et al (2014) Discovery and optimization of an azetidine chemical series as a free fatty acid receptor 2 (FFA2) antagonist: from hit to clinic. J.Med.Chem. 57 10044 PMID: 25380412

If you know of a relevant reference for GLPG 0974, please let us know.

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关键词: GLPG 0974, GLPG 0974 supplier, GLPG0974, free, fatty, acid, receptors, FFA2, antagonists, antagonism, potent, Free, Fatty, Acid, Receptors, 5621, Tocris Bioscience

2 篇 GLPG 0974 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GLPG 0974 的部分引用包括：

Marco et al (2020) Acetate coordinates neutrophil and ILC3 responses against C. difficile through FFAR2. J Exp Med 217 PMID: 31876919

Tsung-Hsien et al (2020) Leuconostoc mesenteroides fermentation produces butyric acid and mediates Ffar2 to regulate blood glucose and insulin in type 1 diabetic mice. Sci Rep 10 7928 PMID: 32404878

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