GM 6001

Cat. No. 2983 10 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Broad spectrum MMP inhibitor

别名： Galardin,Ilomastat

化学名： (2R)-N⁴-Hydroxy-N¹-[(1S)-1-(1H-indol-3-ylmethyl)-2-(methylamino)-2-oxoethyl]-2-(2-methylpropyl)butanediamide

纯度： ≥95% (HPLC)

说明书

引用文献 (10)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for GM 6001

GM 6001 is a broad spectrum MMP inhibitor. Reduces infarct volume following middle cerebral artery occlusion in an ischemic mouse model. Also inhibits human skin fibroblast collagenase (K_i = 0.4 nM).

技术数据 for GM 6001

分子量	388.46
公式	C₂₀H₂₈N₄O₄
储存	Store at -20°C
纯度	≥95% (HPLC)
CAS Number	142880-36-2
PubChem ID	132519
InChI Key	NITYDPDXAAFEIT-DYVFJYSZSA-N
Smiles	O=C(NC)[C@@H](NC([C@@H](CC(NO)=O)CC(C)C)=O)CC2=CNC1=CC=CC=C12

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GM 6001

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	38.85	100

制备储备液 for GM 6001

以下数据基于产品分子量 388.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.87 mL	25.74 mL
5 mM	0.51 mL	2.57 mL	5.15 mL
10 mM	0.26 mL	1.29 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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产品说明书 for GM 6001

分析证书/产品说明书

化学品安全技术说明书

参考文献 for GM 6001

参考文献是支持产品生物活性的出版物。

Shichi et al (2011) Involvement of matrix metalloproteinase-mediated proteolysis of neural cell adhesion molecule in the development of cerebral ischemic neuronal damage. J.Pharmacol.Exp.Ther. 338 701 PMID: 21602423

Grobelny et al (1992) Inhibition of skin fibroblast Col., thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry 31 7152 PMID: 1322694

Chao et al (2007) Leptin stimulates endothelin-1 expression via extracellular signal-regulated kinase by epidermal growth factor receptor transactivation in rat aortic smooth muscle cells. Eur.J.Pharmacol. 573 49 PMID: 17678888

If you know of a relevant reference for GM 6001, please let us know.

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关键词: GM 6001, GM 6001 supplier, GM6001, matrix, metalloproteases, metalloproteinases, MMPs, broad-spectrum, inhibitors, inhibits, Ilomastat, Galardin, Matrix, Metalloprotease, 2983, Tocris Bioscience