Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewGR 125487 sulfamate
说明： Potent and selective 5-HT4 antagonist; active in vivo
化学名： 5-Fluoro-2-methoxy-[1-[2-[(methylsulfonyl)amino]ethyl]-4-piperidinyl]-1H-indole-3-methylcarboxylate sulfamate
纯度： ≥97% (HPLC)
生物活性 for GR 125487 sulfamate
GR 125487 sulfamate is a potent and selective 5-HT4 receptor antagonist (Ki = 0.19 nM for porcine 5-HT4). Centrally active following systemic administration in vivo.
许可信息
Sold for research purposes under agreement from GlaxoSmithKline
技术数据 for GR 125487 sulfamate
| 分子量 | 524.58 |
| 公式 | C19H26FN3O5S.H2NSO3H |
| 储存 | Desiccate at RT |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 859502-43-5 |
| PubChem ID | 6604955 |
| InChI Key | VQJFDBXITIOGJM-UHFFFAOYSA-N |
| Smiles | NS(O)(=O)=O.COC1=C(C(=O)OCC2CCN(CCNS(C)(=O)=O)CC2)C2=CC(F)=CC=C2N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for GR 125487 sulfamate
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| water | 4.27 | 10 温和加热 |
制备储备液 for GR 125487 sulfamate
以下数据基于产品分子量 524.58。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.06 mL | 95.31 mL | 190.63 mL |
| 0.5 mM | 3.81 mL | 19.06 mL | 38.13 mL |
| 1 mM | 1.91 mL | 9.53 mL | 19.06 mL |
| 5 mM | 0.38 mL | 1.91 mL | 3.81 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
产品说明书 for GR 125487 sulfamate
参考文献 for GR 125487 sulfamate
参考文献是支持产品生物活性的出版物。
Galeotti et al (1998) Role of 5-HT4 receptors in the mouse passive avoidance test. J.Pharmacol.Exp.Ther. 286 1115 PMID: 9732367
Horikoshi et al (2001) Possible involvement of 5-HT4 receptors, in addition to 5-HT3 receptors, in the emesis induced by high-dose cisp. in Suncus murinus. Jpn.J.Pharmacol. 85 70 PMID: 11243577
Schiavi et al (1994) Identification of serotonin 5-HT4 recognition sites in the porcine caudate nucleus by radioligand binding. Neuropharmacology 33 543 PMID: 7984293
If you know of a relevant reference for GR 125487 sulfamate, please let us know.
按标靶查看相关产品
按产品操作查看相关产品
关键词: GR 125487 sulfamate, GR 125487 sulfamate supplier, Potent, selective, 5-HT4, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, GR125487, sulfamate, GlaxoSmithKline, GSK, 1658, Tocris Bioscience
2 篇 GR 125487 sulfamate 的引用文献
引用文献是使用了 Tocris 产品的出版物。 GR 125487 sulfamate 的部分引用包括：
Warner-Schmidt et al (2009) Role of p11 in cellular and behavioral effects of 5-HT4 receptor stimulation. Dis Model Mech 29 1937 PMID: 19211900
Orr et al (2015) Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory. J Neurosci 18 423 PMID: 25622143
您是否知道使用了 Tocris GR 125487 sulfamate 的优秀论文？ 请告知我们.
GR 125487 sulfamate 的评论
目前没有该产品的评论。 Be the first to review GR 125487 sulfamate and earn rewards!
Have you used GR 125487 sulfamate?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.