Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewGR 73632
说明： Potent and selective NK1 agonist
纯度： ≥95% (HPLC)
生物活性 for GR 73632
GR 73632 is a potent and selective tachykinin NK1 receptor agonist (EC50 = 2 nM in guinea pig vas deferens). Active in vivo. Intrathecal administration of GR 73632 in mice increases itch behavior.
许可信息
Sold for research purposes under agreement from GlaxoSmithKline
技术数据 for GR 73632
| 分子量 | 766.01 |
| 公式 | C40H59N7O6S |
| 序列 |
FFPLM (Modifications: Phe-1 = delta-Aminovaleryl-Phe, Leu-4 = (methyl)Leu, Met-5 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 133156-06-6 |
| PubChem ID | 119599 |
| InChI Key | HQKPTSSZOJLFBZ-LJADHVKFSA-N |
| Smiles | [H]N([C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(=O)CCCCN |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for GR 73632
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for GR 73632
参考文献 for GR 73632
参考文献是支持产品生物活性的出版物。
Hall and Morton (1991) Novel ligands confirm NK-1 receptor-mediated modulation of neurotransmission in the guinea pig vas deferens preparation. Ann.N.Y.Acad.Sci. 632 404 PMID: 1719888
Meini et al (1995) GR 73,632 and [glu(OBzl)11]substance P are selective agonists for the septide-sensitive tachykinin NK1 receptor in the rat urinary bladder. Neuropeptides 28 99 PMID: 7538205
Sakurada et al (1999) Spinal actions of GR73632, a novel tachykinin NK1 receptor agonist. Peptides 20 301 PMID: 10422886
Sheahan et al (2021) The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch. J.Neurosci. 40 8816 PMID: 33051347
If you know of a relevant reference for GR 73632, please let us know.
按产品操作查看相关产品
关键词: GR 73632, GR 73632 supplier, Potent, selective, NK1, agonists, Tachykinin, Receptors, Neurokinin, GR73632, GlaxoSmithKline, GSK, Receptor, 1669, Tocris Bioscience
6 篇 GR 73632 的引用文献
引用文献是使用了 Tocris 产品的出版物。 GR 73632 的部分引用包括：
Navarro et al (2015) The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Mol Psychiatry 156 627 PMID: 25422875
León et al (2016) Direct actions of kisspeptins on GnRH neurons permit attainment of fertility but are insufficient to fully preserve gonadotropic axis activity. Sci.Rep. 6 19206 PMID: 26755241
Ruiz-Pino et al (2015) Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats. Endocrinology 156 576 PMID: 25490143
Sheahan et al (2020) The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch. J.Neurosci. 40 8816 PMID: 33051347
Sheahan et al (2020) The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch. J.Neurosci. 40 1832 PMID: 33051347
Liu et al (2013) TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis. FASEB J 27 3549 PMID: 23722916
您是否知道使用了 Tocris GR 73632 的优秀论文？ 请告知我们.
GR 73632 的评论
目前没有该产品的评论。 Be the first to review GR 73632 and earn rewards!
Have you used GR 73632?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.