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Submit ReviewGR 73632
说明： Potent and selective NK1 agonist
纯度： ≥95% (HPLC)
生物活性 for GR 73632
GR 73632 is a potent and selective tachykinin NK1 receptor agonist (EC50 = 2 nM in guinea pig vas deferens). Active in vivo. Intrathecal administration of GR 73632 in mice increases itch behavior.
许可信息
Sold for research purposes under agreement from GlaxoSmithKline
技术数据 for GR 73632
| 分子量 | 766.01 |
| 公式 | C40H59N7O6S |
| 序列 |
FFPLM (Modifications: Phe-1 = delta-Aminovaleryl-Phe, Leu-4 = (methyl)Leu, Met-5 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 133156-06-6 |
| PubChem ID | 119599 |
| InChI Key | HQKPTSSZOJLFBZ-LJADHVKFSA-N |
| Smiles | [H]N([C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N1CCC[C@H]1C(=O)N(C)[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(=O)CCCCN |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for GR 73632
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for GR 73632
参考文献 for GR 73632
参考文献是支持产品生物活性的出版物。
Hall and Morton (1991) Novel ligands confirm NK-1 receptor-mediated modulation of neurotransmission in the guinea pig vas deferens preparation. Ann.N.Y.Acad.Sci. 632 404 PMID: 1719888
Meini et al (1995) GR 73,632 and [glu(OBzl)11]substance P are selective agonists for the septide-sensitive tachykinin NK1 receptor in the rat urinary bladder. Neuropeptides 28 99 PMID: 7538205
Sakurada et al (1999) Spinal actions of GR73632, a novel tachykinin NK1 receptor agonist. Peptides 20 301 PMID: 10422886
Sheahan et al (2021) The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch. J.Neurosci. 40 8816 PMID: 33051347
If you know of a relevant reference for GR 73632, please let us know.
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关键词: GR 73632, GR 73632 supplier, Potent, selective, NK1, agonists, Tachykinin, Receptors, Neurokinin, GR73632, GlaxoSmithKline, GSK, Receptor, 1669, Tocris Bioscience
6 篇 GR 73632 的引用文献
引用文献是使用了 Tocris 产品的出版物。 GR 73632 的部分引用包括：
Ruiz-Pino et al (2015) Effects and interactions of tachykinins and dynorphin on FSH and LH secretion in developing and adult rats. Endocrinology 156 576 PMID: 25490143
Liu et al (2013) TRPA1 controls inflammation and pruritogen responses in allergic contact dermatitis. FASEB J 27 3549 PMID: 23722916
Navarro et al (2015) The integrated hypothalamic tachykinin-kisspeptin system as a central coordinator for reproduction. Mol Psychiatry 156 627 PMID: 25422875
Sheahan et al (2020) The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch. J.Neurosci. 40 8816 PMID: 33051347
Sheahan et al (2020) The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch. J.Neurosci. 40 1832 PMID: 33051347
León et al (2016) Direct actions of kisspeptins on GnRH neurons permit attainment of fertility but are insufficient to fully preserve gonadotropic axis activity. Sci.Rep. 6 19206 PMID: 26755241
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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