NK1 Receptors
The neurokinin 1 (NK1) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK2 and NK3 receptors. The NK1 receptor is localized in high concentrations in the CNS (particularly the striatum and amygdala) and peripheral tissues.
NK1 Receptor Agonists |
|
|---|---|
| Cat. No. | Product Name / Activity |
| 1669 | GR 73632 |
| Potent and selective NK1 agonist | |
| 1178 | [Sar9,Met(O2)11]-Substance P |
| Potent and selective NK1 agonist | |
NK1 Receptor Antagonists |
|
| Cat. No. | Product Name / Activity |
| 6486 | Aprepitant |
| Potent long-acting hNK1 antagonist | |
| 3649 | CP 122721 hydrochloride |
| High affinity NK1 antagonist | |
| 2893 | CP 96345 |
| Potent and selective NK1 antagonist | |
| 3417 | CP 99994 dihydrochloride |
| High affinity NK1 antagonist | |
| 2400 | FK 888 |
| High affinity NK1 antagonist | |
| 4647 | GR 203040 |
| Potent and selective NK1 antagonist | |
| 4013 | L 760735 |
| High affinity NK1 antagonist | |
| 1145 | L-733,060 hydrochloride |
| Potent NK1 antagonist | |
| 6642 | QWF |
| NK1 receptor antagonist; MRGPRX2 antagonist | |
| 1635 | RP 67580 |
| Potent and selective NK1 antagonist | |
| 2394 | SDZ NKT 343 |
| Highly selective human NK1 antagonist | |
| 4012 | SR 140333 |
| Potent NK1 antagonist | |
| 6893 | VU 6005649 |
| NK1 receptor antagonist; also positive allosteric modulator of mGlu7 and mGlu8 receptors; brain penetrant | |
The neurokinin 1 (NK1) receptor is a member of the tachykinin family of G-protein-coupled receptors which also includes NK2 and NK3 receptors. The NK1 receptor is localized in high concentrations in the CNS (particularly the striatum, amygdala and some hypothalamic and thalamic nuclei) and peripheral tissues.
NK1 receptors are thought to mediate central stress reactions, mood control, excitatory neurotransmission, immune modulation and airway and lung function. The receptor displays greater potency for the endogenous agonist substance P than Neurokinin A and Neurokinin B (SP > NKA > NKB). The human gene encoding the NK1 receptor has been localized on chromosome 2 (2p13.1-p12).
External sources of pharmacological information for NK1 Receptors :
Literature for NK1 Receptors
Tocris offers the following scientific literature for NK1 Receptors to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Our Peptides Involved in Appetite Modulation review gives an overview of the peptides implicated in appetite regulation and energy homeostasis.
Request copyRequest PDFWritten by P. Skolnich et al
Our Depression poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder.
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