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Submit ReviewGRI 977143
说明： Selective LPA2 receptor non-lipid agonist
化学名： 2-[[3-(1,3-dioxo-1H-benz[de]isoquinolin-2(3H)-yl)propyl]thio]benzoic acid
纯度： ≥98% (HPLC)
生物活性 for GRI 977143
GRI 977143 is a selective lysophosphatidic acid 2 (LPA2) receptor non-lipid agonist (EC50 = 3.3 μM). Does not activate other LPA GPCRs at concentrations up to 10 μM. Antiapoptotic; inhibits activation of caspases 3, 7, 8 and 9, Bax translocation and PARP-1 cleavage. Activates ERK1/2 survival pathway.
技术数据 for GRI 977143
| 分子量 | 391.44 |
| 公式 | C22H17NO4S |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 325850-81-5 |
| PubChem ID | 3114900 |
| InChI Key | GMVZUCHUOYUMLL-UHFFFAOYSA-N |
| Smiles | O=C(C2=CC=CC3=CC=CC(C4=O)=C23)N4CCCSC1=CC=CC=C1C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for GRI 977143
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 39.14 | 100 |
制备储备液 for GRI 977143
以下数据基于产品分子量 391.44。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.55 mL | 12.77 mL | 25.55 mL |
| 5 mM | 0.51 mL | 2.55 mL | 5.11 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.55 mL |
| 50 mM | 0.05 mL | 0.26 mL | 0.51 mL |
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产品说明书 for GRI 977143
参考文献 for GRI 977143
参考文献是支持产品生物活性的出版物。
Kiss et al (2012) Virtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions. Mol.Pharmacol. 82 1162 PMID: 22968304
Kiss et al (2013) Mitigation of radiation injury by selective stimulation of the LPA(2) receptor. Biochim.Biophys.Acta 1831 117 PMID: 23127512
If you know of a relevant reference for GRI 977143, please let us know.
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关键词: GRI 977143, GRI 977143 supplier, GRI977143, lysophospholipid, acid, 2, LPA2, inhibitors, inhibits, antiapoptotic, caspases, Bax, PARP-1, cleavage, ERK1/2, ERK, survival, pathway, apoptosis, Other, Apoptosis, Lysophosphatidic, Acid, Receptors, 4779, Tocris Bioscience
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