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Submit ReviewGRP (human)
说明： Endogenous GRP receptor agonist
别名： Gastrin-releasing peptide (human)
纯度： ≥95% (HPLC)
生物活性 for GRP (human)
GRP (human) is a mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI tract and appetite regulation.
技术数据 for GRP (human)
| 分子量 | 2859.4 |
| 公式 | C130H204N38O31S2 |
| 序列 |
VPLPAGGGTVLTKMYPRGNHWAVGHLM (Modifications: Met-27 = C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 93755-85-2 |
| PubChem ID | 16143985 |
| InChI Key | PUBCCFNQJQKCNC-XKNFJVFFSA-N |
| Smiles | [H]N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for GRP (human)
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for GRP (human)
参考文献 for GRP (human)
参考文献是支持产品生物活性的出版物。
Benya et al (1995) Expression and characterization of cloned human bombesin receptors. Mol.Pharmacol. 47 10 PMID: 7838118
Dudai (2003) Neurobiology: Fear thou not. Nature 421 325 PMID: 12540884
Shumyatsky et al (2002) Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell 111 905 PMID: 12526815
Woodruff et al (1996) Bombesin receptors in the brain. Ann.N.Y.Acad.Sci. 780 223 PMID: 8602736
If you know of a relevant reference for GRP (human), please let us know.
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关键词: GRP (human), GRP (human) supplier, Endogenous, GRP, receptor, agonists, GRP-Preferring, Receptors, BB2, Gastrin-Releasing, Peptide-Preferring, Bombesin, Gastrin-releasing, peptide, (human), 1789, Tocris Bioscience
6 篇 GRP (human) 的引用文献
引用文献是使用了 Tocris 产品的出版物。 GRP (human) 的部分引用包括：
Solorzano et al (2015) Primary afferent and spinal cord expression of gastrin-releasing peptide: message, protein, and antibody concerns. Sci Rep 35 648 PMID: 25589759
Blais et al (2016) Gastrin-releasing peptide receptor mediates the excitation of preoptic GABAergic neurons by bombesin Neuroscience Letters 633 262 PMID: 27693662
Gey et al (2016) Atf3 mutant mice show reduced axon regeneration and impaired regeneration-associated gene induction after peripheral nerve injury. Open Biol 6 PMID: 27581653
Shehan et al (2020) The neurokinin-1 receptor is expressed with gastrin-releasing peptide receptor in spinal interneurons and modulates itch. J Neurosci 40 8816 PMID: 33051347
Kim et al (2013) Enhanced autophagy blocks angiogenesis via degradation of gastrin-releasing peptide in neuroblastoma cells. J Neurosci 9 1579 PMID: 24108003
Lee and Ko (2015) Distinct functions of opioid-related peptides and gastrin-releasing peptide in regulating itch and pain in the spinal cord of primates. Int J Inflam 5 11676 PMID: 26119696
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.