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Submit ReviewGRP (porcine)
说明： Endogenous GRP receptor agonist
别名： Gastrin-releasing peptide (porcine)
生物活性 for GRP (porcine)
GRP (porcine) is a mammalian bombesin-like peptide neurotransmitter that is an agonist for the gastrin-releasing peptide receptor (GRPR). GRP has been reported to activate GABAergic interneurons in the amygdala leading to increased GABA release and fear suppression in mice in vivo. Also involved in mitogenesis, and GI tract and appetite regulation.
技术数据 for GRP (porcine)
| 分子量 | 2805.31 |
| 公式 | C126H198N38O31S2 |
| 序列 |
APVSVGGGTVLAKMYPRGNHWAVGHLM (Modifications: Met-27 = C-terminal amide) |
| 储存 | Desiccate at -20°C |
| CAS Number | 74815-57-9 |
| PubChem ID | 16132336 |
| InChI Key | GLCDCQPXUJKYKQ-GZDVRPNBSA-N |
| Smiles | [H]N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)NCC(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)NCC(=O)N[C@@H](CC1=CNC=N1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for GRP (porcine)
参考文献 for GRP (porcine)
参考文献是支持产品生物活性的出版物。
Dudai (2003) Neurobiology: Fear thou not. Nature 421 325 PMID: 12540884
Schjoldager et al (1991) Gastrin-releasing peptide is a transmitter mediating porcine gallbladder contraction. Am.J.Physiol. 260 G577 PMID: 1708207
Shumyatsky et al (2002) Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear. Cell 111 905 PMID: 12526815
Woodruff et al (1996) Bombesin receptors in the brain. Ann.N.Y.Acad.Sci. 780 223 PMID: 8602736
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关键词: GRP (porcine), GRP (porcine) supplier, Endogenous, GRP, receptor, agonists, GRP-Preferring, Receptors, BB2, Gastrin-Releasing, Peptide-Preferring, Bombesin, Gastrin-releasing, peptide, (porcine), 1788, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.