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GSK 2194069

Cat. No. 5303 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent human fatty acid synthase (hFASN) inhibitor
化学名： 4-[4-(5-Benzofuranyl)phenyl]-5-[[(3S)-1-(cyclopropylcarbonyl)-3-pyrrolidinyl]methyl]-2,4-dihydro-3H-1,2,4-triazol-3-one
纯度： ≥99% (HPLC)
说明书
引用文献 (4)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GSK 2194069

GSK 2194069 is a potent human fatty acid synthase (hFASN) inhibitor (IC50 = 7.7 nM); inhibits hFAS β-ketoacyl reductase activity. Inhibits lipid synthesis and attenuates proliferation of A549 non-small-cell lung cancer cells (EC50 = 15 nM) in vitro. GSK 2194069 also inhibits infection by SARS-CoV-2 (EC50 = 0.9 nM) in vitro.

化合物库 for GSK 2194069

GSK 2194069 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for GSK 2194069

分子量 428.48
公式 C25H24N4O3
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 1332331-08-4
PubChem ID 67376285
InChI Key AQTPWCUIYUOEMG-INIZCTEOSA-N
Smiles O=C1NN=C(C[C@@H]2CCN(C(C3CC3)=O)C2)N1C4=CC=C(C5=CC=C(OC=C6)C6=C5)C=C4

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GSK 2194069

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 42.85 100
ethanol 8.57 20

制备储备液 for GSK 2194069

以下数据基于产品分子量 428.48。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.33 mL 11.67 mL 23.34 mL
5 mM 0.47 mL 2.33 mL 4.67 mL
10 mM 0.23 mL 1.17 mL 2.33 mL
50 mM 0.05 mL 0.23 mL 0.47 mL

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参考文献 for GSK 2194069

参考文献是支持产品生物活性的出版物。

Hardwicke et al (2014) A human fatty acid synthase inhibitor binds β-ketoacyl reductase in the keto-substrate site. Nat.Chem.Biol. 10 774 PMID: 25086508

Chu et al (2021) Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. Nat.Metab. 3 1466 PMID: 34580494

If you know of a relevant reference for GSK 2194069, please let us know.

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关键词: GSK 2194069, GSK 2194069 supplier, GSK2194069, fatty, acid, synthases, hFAS, beta-ketoacyl, reductases, b-ketoacyl, β-ketoacyl, lipid, synthesis, inhibitors, inhibits, Fatty, Acid, Synthase, Coronavirus, 5303, Tocris Bioscience

4 篇 GSK 2194069 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GSK 2194069 的部分引用包括：

Chu et al (2021) Pharmacological inhibition of fatty acid synthesis blocks SARS-CoV-2 replication. Nat.Metab. 3 1466 PMID: 34580494

Lien et al (2021) Low glycaemic diets alter lipid metabolism to influence tumour growth. Nature 599 302 PMID: 34671163

Wu and Näär (2019) SREBP1-dependent de novo fatty acid synthesis gene expression is elevated in malignant melanoma and represents a cellular survival trait. Sci Rep 9 10369 PMID: 31316083

Evan C et al (2022) Cancer cells depend on environmental lipids for proliferation when electron acceptors are limited. Nat Metab 4 711-723 PMID: 35739397

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