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GSK 2795039

Cat. No. 6848 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： NADPH oxidase 2 (NOX2) inhibitor
化学名： N-[3-(2,3-Dihydro-1-methyl-1H-indol-6-yl)-1-(1-methylethyl)-1H-pyrrolo[2,3-b]pyridin-4-yl]-1-methyl-1H-pyrazole-3-sulfonamide
纯度： ≥98% (HPLC)
说明书
引用文献
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文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GSK 2795039

GSK 2795039 is a NADPH oxidase 2 (NOX2) inhibitor (pIC50 value is 5.5 to 6.5, depending on assay performed), which displays selectivity for NOX2 other NOX isoforms, xanthine oxidase and eNOS. GSK 2795039 inhibits reactive oxygen species (ROS) in cellular assays, and displays efficacy in rodent models of paw inflammation and acute pancreatitis.

化合物库 for GSK 2795039

GSK 2795039 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for GSK 2795039

分子量 450.56
公式 C23H26N6O2S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1415925-18-6
PubChem ID 71090129
InChI Key FMWVTCZKCXPKFW-UHFFFAOYSA-N
Smiles CC(N1C=C(C2=CC=C3CCN(C3=C2)C)C4=C(C=CN=C14)NS(=O)(C5=NN(C=C5)C)=O)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GSK 2795039

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 45.06 100

制备储备液 for GSK 2795039

以下数据基于产品分子量 450.56。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.1 mL 22.19 mL
5 mM 0.44 mL 2.22 mL 4.44 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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参考文献 for GSK 2795039

参考文献是支持产品生物活性的出版物。

Hirano et al (2015) Discovery of GSK2795039, a novel small molecule NADPH oxidase 2 inhibitor. Antioxid.Redox.Signal. 23 358 PMID: 26135714

If you know of a relevant reference for GSK 2795039, please let us know.

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关键词: GSK 2795039, GSK 2795039 supplier, GSK2795039, NOX2, NADPH, oxidase, inhibitors, inhibits, reactive, oxygen, species, ROS, CYBB, cytochrome, b-245, beta, chain, Oxidase, 6848, Tocris Bioscience

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