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GSK 3787

Cat. No. 3961 4 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective PPARδ antagonist
化学名： 4-Chloro-N-[2-[[5-(trifluoromethyl)-2-pyridinyl]sulfonyl]ethyl]benzamide
纯度： ≥99% (HPLC)
说明书
引用文献 (4)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GSK 3787

GSK 3787 is a potent and selective peroxisome proliferator-activated receptor δ (PPARδ) antagonist (pIC50 = 6.6). Displays no measurable affinity for PPARα or PPARγ in vitro (pIC50< 5).

化合物库 for GSK 3787

GSK 3787 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for GSK 3787

分子量 392.78
公式 C15H12ClF3N2O3S
储存 Store at +4°C
纯度 ≥99% (HPLC)
CAS Number 188591-46-0
PubChem ID 2800647
InChI Key JFUIMTGOQCQTPF-UHFFFAOYSA-N
Smiles O=C(C2=CC=C(Cl)C=C2)NCCS(C1=CC=C(C(F)(F)F)C=N1)(=O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GSK 3787

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 39.28 100

制备储备液 for GSK 3787

以下数据基于产品分子量 392.78。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.55 mL 12.73 mL 25.46 mL
5 mM 0.51 mL 2.55 mL 5.09 mL
10 mM 0.25 mL 1.27 mL 2.55 mL
50 mM 0.05 mL 0.25 mL 0.51 mL

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产品说明书 for GSK 3787

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for GSK 3787

参考文献是支持产品生物活性的出版物。

Shearer et al (2010) Identification and characterization of 4-chloro-N(2-{[5-trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide (GSK3787), a selective and irreversible peroxisome proliferator-activated receptor delta (PPARdelta) antagonist. J.Med.Chem. 53 1857 PMID: 20128594

Palkar et al (2010) Cellular and pharmacological selectivity of the peroxisone proliferator-activated receptor-β/δ antagonist GSK3787. Mol.Pharmacol. 78 419 PMID: 20516370

If you know of a relevant reference for GSK 3787, please let us know.

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关键词: GSK 3787, GSK 3787 supplier, GSK3787, peroxisome, proliferator-activated, receptor, PPARd, PPARdelta, PPARδ, antagonists, Receptors, 3961, Tocris Bioscience

4 篇 GSK 3787 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GSK 3787 的部分引用包括：

Samokhvalov et al (2015) PPARδ signaling mediates the cytotoxicity of DHA in H9c2 cells. Cell Cycle 232 44105 PMID: 25300478

Massimo et al (2022) Peroxisome Proliferator-Activated Receptor Activation in Precision-Cut Bovine Liver Slices Reveals Novel Putative PPAR Targets in Periparturient Dairy Cows. Front Vet Sci 9 931264 PMID: 35903133

Ning et al (2023) Nuclear receptor modulators inhibit osteosarcoma cell proliferation and tumour growth by regulating the mTOR signaling pathway. Cell Death Dis 14 51 PMID: 36681687

Sebastiano et al (2020) The interplay between non-esterified fatty acids and bovine peroxisome proliferator-activated receptors: results of an in vitro hybrid approach. J Anim Sci Biotechnol 11 91 PMID: 32793344

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