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GSK 591 dihydrochloride

Cat. No. 5777 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Potent and selective PRMT5 inhibitor
别名： EPZ015866,GSK 3203591
化学名： 2-(Cyclobutylamino)-N-[(2S)-3-(3,4-dihydro-2(1H)-isoquinolinyl)-2-hydropropyl]-4-pyridinecarboxamide dihydrochloride
纯度： ≥97% (HPLC)
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引用文献
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生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for GSK 591 dihydrochloride

GSK 591 dihydrochloride is a potent and selective PRMT5 inhibitor (IC50 = 4 nM). Selective for PRMT5 over a panel of other PRMTs and lysine methyltransferases. Inhibits proliferation of mantle cell lymphoma (MCL) in vitro.

To request the negative control for GSK 591, please fill out the SGC 2096 request form on the SGC website.

许可信息

This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the GSK591 probe summary on the SGC website.

External Portal Information for GSK 591 dihydrochloride

Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GSK591 is reviewed on the Chemical Probes website.

化合物库 for GSK 591 dihydrochloride

GSK 591 dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for GSK 591 dihydrochloride

分子量 453.41
公式 C22H28N4O2.2HCl
储存 Desiccate at RT
纯度 ≥97% (HPLC)
CAS Number 2320953-89-5
PubChem ID 124201849
InChI Key CDKUMVXFXBTOBE-FJSYBICCSA-N
Smiles O[C@@H](CNC(C1=CC=NC(NC2CCC2)=C1)=O)CN3CC4=CC=CC=C4CC3.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GSK 591 dihydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 45.34 100
DMSO 45.34 100

制备储备液 for GSK 591 dihydrochloride

以下数据基于产品分子量 453.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.21 mL 11.03 mL 22.06 mL
5 mM 0.44 mL 2.21 mL 4.41 mL
10 mM 0.22 mL 1.1 mL 2.21 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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产品说明书 for GSK 591 dihydrochloride

分析证书/产品说明书
化学品安全技术说明书

参考文献 for GSK 591 dihydrochloride

参考文献是支持产品生物活性的出版物。

Duncan et al (2015) Structure and property guided design in the identification of PRMT5 tool compound EPZ015666. ACS.Med.Chem.Lett. 7 162 PMID: 26985292

Scheer et al (2019) A chemical biology toolbox to study protein methyltransferases and epigenetic signaling. Nat.Commun. 10 19 PMID: 30604761

If you know of a relevant reference for GSK 591 dihydrochloride, please let us know.

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关键词: GSK 591 dihydrochloride, GSK 591 dihydrochloride supplier, GSK591, dihydrochloride, protein, arginine, methyltransferases, inhibitors, inhibits, potent, selective, PRMT5, 1616391-87-7, Structural, Genomics, Consortium, SGC, GSK3203591, EPZ015866, GSK, 3203591, Protein, Arginine, Methyltransferases, 5777, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

Epigenetics Scientific Review

Epigenetics Scientific Review

Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.