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Submit ReviewGSK 5959
说明： Potent and selective BRPF1 inhibitor
化学名： N-[2,3-Dihydro-1,3-dimethyl-2-oxo-6-(1-piperidinyl)-1H-benzimidazol-5-yl]-2-methoxybenzamide
纯度： ≥99% (HPLC)
生物活性 for GSK 5959
GSK 5959 is a potent and selective BRPF1 bromodomain inhibitor (IC50 = 80 nM). Exhibits >100-fold selectivity for BRPF1 over a panel of 35 other bromodomains, including BRPF2/3 and BET family bromodomains. Inhibits BRPF1 interaction with histone H3.3. Cell permeable.
External Portal Information for GSK 5959
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of GSK 5959 is reviewed on the chemical probes website.
技术数据 for GSK 5959
| 分子量 | 394.47 |
| 公式 | C22H26N4O3 |
| 储存 | Store at +4°C |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 901245-65-6 |
| PubChem ID | 15990224 |
| InChI Key | LTUGYAOMCKNTGG-UHFFFAOYSA-N |
| Smiles | CN(C1=CC(NC(C4=C(OC)C=CC=C4)=O)=C(N3CCCCC3)C=C1N2C)C2=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for GSK 5959
参考文献 for GSK 5959
参考文献是支持产品生物活性的出版物。
Demont et al (2014) 1,3-dimethyl benzimidazolones are potent, selective inhibitors of the BRPF1 bromodomain. ACS Med.Chem.Lett. 5 1190 PMID: 25408830
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关键词: GSK 5959, GSK 5959 supplier, GSK5959, potent, selective, BRPF1, bromodomains, inhibitors, inhibits, cell, permeable, Bromodomains, 5385, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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