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GTS 21 dihydrochloride

Cat. No. 4557 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4557 has been discontinued.

说明： α7 nAChR partial agonist
别名： DMXBA
化学名： 3-[(2,4-Dimethoxyphenyl)methylene]-3,4,5,6-tetrahydro-2,3'-bipyridine dihydrochloride
纯度： ≥98% (HPLC)
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生物活性 技术数据 说明书 参考文献

生物活性 for GTS 21 dihydrochloride

GTS 21 dihydrochloride is a partial agonist of α7 nicotinic acetylcholine receptors (nAChRs); also a weak α4β2 and 5-HT3 antagonist at micromolar concentrations. Exhibits improved sensory inhibition in DBA/2 mice following both acute and chronic administration. Also shown to improve memory in several animal models; facilitates hippocampal long-term potentiation. Also has anti-inflammatory effects independent of α7 nAChRs.

技术数据 for GTS 21 dihydrochloride

分子量 381.3
公式 C19H20N2O2.2HCl
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 156223-05-1
PubChem ID 122225
InChI Key BXKYFUGAAFLYJL-UHFFFAOYSA-N
Smiles COC(C=C3OC)=CC=C3\C=C1C(C2=CC=CN=C2)=NCCC/1.Cl.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

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参考文献 for GTS 21 dihydrochloride

参考文献是支持产品生物活性的出版物。

Stevens et al (2010) Continuous administration of a selective alpha7 nicotinic partial agonist, DMXBA, improves sensory inhibition without causing tachyphylaxis or receptor upregulation in DBA/2 mice. Brain.Res. 1352 140 PMID: 20599427

Meyer et al (1994) Effects of anabaseine-related analogs on rat brain nicotinic receptor binding and on avoidance behaviors. Drug Dev.Res. 31 127

Olincy et al (2012) Nicotinic mechanisms in the treatment of psychotic disorders: a focus on the a7 nicotinic receptor. Handb.Exp.Pharmacol. 213 211 PMID: 23027417

Garg and Loring et al (2019) GTS-21 has cell-specific anti-inflammatory effects independent of a7 nicotinic acetylcholine receptors. PLoS One 14 e0214942 PMID: 30947238

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关键词: GTS 21 dihydrochloride, GTS 21 dihydrochloride supplier, GTS21, dihydrochloride, partial, agonist, a7, nAChR, nicotinic, acetylcholine, receptor, α7, agonists, a4b2, α4, β2, anti, inflammatory, Alzheimer's, disease, DMXBA, alpha7, alpha4beta2, Nicotinic, (a7), Receptors, 4557, Tocris Bioscience

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