GW 0742

Cat. No. 2229 14 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Highly selective, potent PPARδ agonist

化学名： [4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid

纯度： ≥98% (HPLC)

引用文献 (14)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for GW 0742

GW 0742 is a potent and highly selective PPARδ agonist. EC₅₀ values are 0.001, 1.1 and 2 μM for transactivation of human PPARδ, -α, and -γ receptors respectively. Neuroprotective in rat cerebellar granule neuronal cultures after brief (12-hour) exposure but exhibits inherent toxicity after prolonged (48-hour) incubation. Increases rate of fatty acid oxidation and protects against ischemia/reperfusion injury in neonatal and adult cardiomyocytes.

许可信息

Sold for research purposes under agreement from GlaxoSmithKline

化合物库 for GW 0742

GW 0742 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for GW 0742

分子量	471.49
公式	C₂₁H₁₇F₄NO₃S₂
储存	Desiccate at +4°C
纯度	≥98% (HPLC)
CAS Number	317318-84-6
PubChem ID	9934458
InChI Key	HWVNEWGKWRGSRK-UHFFFAOYSA-N
Smiles	CC1=C(CSC2=CC(C)=C(OCC(O)=O)C=C2)SC(=N1)C1=CC(F)=C(C=C1)C(F)(F)F

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GW 0742

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	ethanol	24.23	50
	DMSO	48.5	100

制备储备液 for GW 0742

以下数据基于产品分子量 471.49。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.12 mL	10.6 mL	21.21 mL
5 mM	0.42 mL	2.12 mL	4.24 mL
10 mM	0.21 mL	1.06 mL	2.12 mL
50 mM	0.04 mL	0.21 mL	0.42 mL

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产品说明书 for GW 0742

分析证书/产品说明书

化学品安全技术说明书

参考文献 for GW 0742

参考文献是支持产品生物活性的出版物。

Sznaidman et al (2003) Novel selective small molecule agonists for peroxisome proliferator-activated receptor δ (PPARδ) - Synthesis and biological activity. Bioorg.Med.Chem.Lett. 13 1517 PMID: 12699745

Smith et al (2004) Effect of the peroxisome proliferator-activated receptor β activator GW0742 in rat cultured cerebellar granule neurons. J.Neurosci.Res. 77 240 PMID: 15211590

Yue et al (2008) In vivo activation of peroxisome proliferator-activayed receptor-δ protects the heart from ischemia/reperfusion injury in Zucker fatty rats. J.Pharm.Exp.Ther. 325 466

If you know of a relevant reference for GW 0742, please let us know.

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关键词: GW 0742, GW 0742 supplier, selective, potent, PPARδ, PPARdelta, agonists, Peroxisome, Proliferator-activating, Receptors, GW0742, GlaxoSmithKline, GSK, 2229, Tocris Bioscience