GW 438014A

Name: GW 438014A
Brand: Tocris Bioscience
SKU: 4669

Cat. No. 4669 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4669 has been discontinued.

View all NPY Receptors products.

说明： NPY Y₅ receptor antagonist

化学名： N-[1-(2-Phenylethyl)-1H-benzimidazol-2-yl]benzamide methanesulfonate

纯度： ≥99% (HPLC)

说明书

引用文献

文献 (1)

生物活性技术数据说明书参考文献

生物活性 for GW 438014A

Neuropeptide (NPY) Y₅ receptor antagonist (IC₅₀ = 210 nM). Reduces NPY-induced food intake in rodents and decreases weight gain in obese rats.

许可信息

Sold for research purposes under agreement from GlaxoSmithKline.

技术数据 for GW 438014A

分子量	437.51
公式	C₂₂H₁₉N₃O.CH₃SO₃H
储存	Store at +4°C
纯度	≥99% (HPLC)
CAS Number	469861-49-2
PubChem ID	6918626
InChI Key	AVYFZOKRFCFQLP-UHFFFAOYSA-N
Smiles	O=C(C4=CC=CC=C4)NC2=NC1=CC=CC=C1N2CCC3=CC=CC=C3.CS(=O)(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for GW 438014A

分析证书/产品说明书

化学品安全技术说明书

参考文献 for GW 438014A

参考文献是支持产品生物活性的出版物。

Daniels et al (2002) Food intake inhibition and reduction in body weight gain in lean and obese rodents treated with GW438014A, a potent and selective NPY-Y₅ receptor antagonist. Regul.Pept. 106 47 PMID: 12047910

Benmaamar et al (2005) Neuropeptide Y Y₅ receptors inhibit kindling acquisition in rats. Regul.Pept. 125 79 PMID: 15582717

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关键词: GW 438014A, GW 438014A supplier, GW438014A, neuropeptide, Y, NPY, Y5, receptors, antagonists, obesity, Receptors, 4669, Tocris Bioscience

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该领域的文献

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Peptides Involved in Appetite Modulation Scientific Review

Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.