GW 583340 dihydrochloride

Cat. No. 2239 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent dual EGFR/ErbB2 inhibitor; orally active

化学名： N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinamine dihydrochloride

纯度： ≥97% (HPLC)

引用文献 (1)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for GW 583340 dihydrochloride

GW 583340 dihydrochloride is a potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC₅₀ values are 0.01 and 0.014 μM respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2 (IC₅₀ values are 0.11 μM for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μM for inhibition of non-tumor cell line HFF). Inhibits tumor growth in vivo by ~ 80% in a murine xenograft model following oral administration.

许可信息

Sold for research purposes under agreement from GlaxoSmithKline.

化合物库 for GW 583340 dihydrochloride

GW 583340 dihydrochloride is also offered as part of the Tocriscreen Kinase Inhibitor Library. 了解 Tocris 化合物库的更多信息。

技术数据 for GW 583340 dihydrochloride

分子量	671.03
公式	C₂₈H₂₅ClFN₅O₃S₂.2HCl
储存	Desiccate at +4°C
纯度	≥97% (HPLC)
CAS Number	1173023-85-2
PubChem ID	16219404
InChI Key	WIMITXDBYLKRKB-UHFFFAOYSA-N
Smiles	Cl.Cl.CS(=O)(=O)CCNCC1=NC(=CS1)C1=CC=C2N=CN=C(NC3=CC=C(OCC4=CC=CC(F)=C4)C(Cl)=C3)C2=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for GW 583340 dihydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	67.1	100 温和加热

制备储备液 for GW 583340 dihydrochloride

以下数据基于产品分子量 671.03。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.49 mL	7.45 mL	14.9 mL
5 mM	0.3 mL	1.49 mL	2.98 mL
10 mM	0.15 mL	0.75 mL	1.49 mL
50 mM	0.03 mL	0.15 mL	0.3 mL

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产品说明书 for GW 583340 dihydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for GW 583340 dihydrochloride

参考文献是支持产品生物活性的出版物。

Gaul et al (2003) Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines. Bioorg.Med.Chem.Lett. 13 637 PMID: 12639547

If you know of a relevant reference for GW 583340 dihydrochloride, please let us know.

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1 篇 GW 583340 dihydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 GW 583340 dihydrochloride 的部分引用包括：

Sodani et al (2012) GW583340 and GW2974, human EGFR and HER-2 inhibitors, reverse ABCG2- and ABCB1-mediated drug resistance. Biochem Pharmacol 83 1613 PMID: 22414725

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