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Submit ReviewGW 9508
说明： Potent and selective FFA1 (GPR40) agonist
化学名： 4-[[(3-Phenoxyphenyl)methyl]amino]benzenepropanoic acid
纯度： ≥99% (HPLC)
生物活性 for GW 9508
GW 9508 is a potent and selective agonist for the free fatty acid receptor FFA1 (GPR40) (pEC50 values are 7.32, < 4.3 and < 4.3 for FFA1, FFA2 and FFA3 receptors respectively). Inactive against a range of other GPCRs, kinases, proteases, integrins and PPARs. Potentiates glucose-stimulated insulin secretion in MIN6 cells (pEC50 = 6.14).
许可信息
Sold with the permission of GlaxoSmithKline
化合物库 for GW 9508
GW 9508 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for GW 9508
| 分子量 | 347.41 |
| 公式 | C22H21NO3 |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 885101-89-3 |
| PubChem ID | 11595431 |
| InChI Key | DGENZVKCTGIDRZ-UHFFFAOYSA-N |
| Smiles | OC(=O)CCC1=CC=C(NCC2=CC=CC(OC3=CC=CC=C3)=C2)C=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for GW 9508
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 34.74 | 100 | |
| ethanol | 34.74 | 100 |
制备储备液 for GW 9508
以下数据基于产品分子量 347.41。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.88 mL | 14.39 mL | 28.78 mL |
| 5 mM | 0.58 mL | 2.88 mL | 5.76 mL |
| 10 mM | 0.29 mL | 1.44 mL | 2.88 mL |
| 50 mM | 0.06 mL | 0.29 mL | 0.58 mL |
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产品说明书 for GW 9508
参考文献 for GW 9508
参考文献是支持产品生物活性的出版物。
Garrido et al (2006) Synthesis and activity of small molecule GPR40 agonists. Bioorg.Med.Chem.Lett. 16 1840 PMID: 16439116
Briscoe et al (2006) Pharmacological regulation of Ins secretion in MIN6 cells through fatty acid receptor GPR40: identification of agonist and antagonist small molecules. Br.J.Pharmacol. 148 619 PMID: 16702987
Zhao and Chen (2008) Activation of ATP-sensitive potassium channels in rat pancreatic β-cells by linoleic acid through both intracellular metabolites and membrane receptor signalling pathway. J.Endocrinol. 198 533 PMID: 18550787
If you know of a relevant reference for GW 9508, please let us know.
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关键词: GW 9508, GW 9508 supplier, Potent, selective, FFA1, GPR40, agonists, Receptors, Free, Fatty, Acid, GW9508, GlaxoSmithKline, GSK, 2649, Tocris Bioscience
3 篇 GW 9508 的引用文献
引用文献是使用了 Tocris 产品的出版物。 GW 9508 的部分引用包括：
Oh et al (2010) GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and Ins-sensitizing effects. Cell 142 687 PMID: 20813258
Dragano (2017) Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation. J Neuroinflammation 14 91 PMID: 28446241
Watson et al (2012) Differential signaling by splice variants of the human free fatty acid receptor GPR120. Mol Pharmacol 81 631 PMID: 22282525
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