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H 151

Cat. No. 6675 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： STING antagonist
化学名： N-(4-Ethylphenyl)-N'-1H-indol-3-yl-urea
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for H 151

H 151 is a STING antagonist. Covalently binds STING at Cys91, blocking palmitoylation and preventing assembly of STING clusters. Decreases inflammatory cytokine production in human and mouse cells in vitro. Also blocks CMA (Cat. No. 6677) -induced increases in levels of inflammatory cytokines in mice, and alleviates systemic inflammation in a mouse model of autoinflammatory disease.

化合物库 for H 151

H 151 is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for H 151

分子量 279.34
公式 C17H17N3O
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 941987-60-6
PubChem ID 7616033
InChI Key UJZDIKVQFMCLBE-UHFFFAOYSA-N
Smiles CCC1=CC=C(C=C1)NC(NC2=CNC3=CC=CC=C23)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for H 151

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 27.93 100
ethanol 13.97 50

制备储备液 for H 151

以下数据基于产品分子量 279.34。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.58 mL 17.9 mL 35.8 mL
5 mM 0.72 mL 3.58 mL 7.16 mL
10 mM 0.36 mL 1.79 mL 3.58 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

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产品说明书 for H 151

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for H 151

参考文献是支持产品生物活性的出版物。

Haag et al (2018) Targeting STING with covalent small-molecule inhibitors. Nature 559 269 PMID: 29973723

If you know of a relevant reference for H 151, please let us know.

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关键词: H 151, H 151 supplier, H151, STING, antagonist, antagonism, anti-inflammatory, covalent, STING-Dependent, Signaling, 6675, Tocris Bioscience

2 篇 H 151 的引用文献

引用文献是使用了 Tocris 产品的出版物。 H 151 的部分引用包括：

Kevin C et al (2023) Innate immune signaling drives late cardiac toxicity following DNA-damaging cancer therapies. J Exp Med 220 PMID: 36534085

Ying et al (2023) STING Suppresses Mitochondrial VDAC2 to Govern RCC Growth Independent of Innate Immunity. Adv Sci (Weinh) 10 e2203718 PMID: 36445063

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