H2L5186303

Name: H2L5186303
Brand: Tocris Bioscience
SKU: 4878
Rating: 4 (1 reviews)

Cat. No. 4878 6 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Potent and selective LPA₂ receptor antagonist

化学名： (Z,Z)-4,4'-[1,3-Phenylenebis(oxy-4,1-phenyleneimino)]bis[4-oxo-2-butenoic acid

纯度： ≥98% (HPLC)

说明书

引用文献 (6)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for H2L5186303

H2L5186303 is a potent and selective lysophosphatidic acid 2 (LPA₂) receptor antagonist (IC₅₀ values are 8.9, 1230 and 27354 nM for LPA₂, LPA₃ and LPA₁ receptors respectively, in a LPA-elicited calcium mobilization assay).

技术数据 for H2L5186303

分子量	488.45
公式	C₂₆H₂₀N₂O₈
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	139262-76-3
PubChem ID	90488981
InChI Key	HZFPOTBCYPWQSH-DZDAAMPGSA-N
Smiles	O=C(/C=C\C(O)=O)NC(C=C3)=CC=C3OC1=CC(OC2=CC=C(NC(/C=C\C(O)=O)=O)C=C2)=CC=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for H2L5186303

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	48.84	100

制备储备液 for H2L5186303

以下数据基于产品分子量 488.45。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	2.05 mL	10.24 mL	20.47 mL
5 mM	0.41 mL	2.05 mL	4.09 mL
10 mM	0.2 mL	1.02 mL	2.05 mL
50 mM	0.04 mL	0.2 mL	0.41 mL

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产品说明书 for H2L5186303

分析证书/产品说明书

化学品安全技术说明书

参考文献 for H2L5186303

参考文献是支持产品生物活性的出版物。

Fells et al (2008) Identification of non-lipid LPA₃ antagonists by virtual screening. Bioorg.Med.Chem. 16 6207 PMID: 18467108

Fells et al (2009) Structure-based drug design identifies novel LPA₃ antagonists. Bioorg.Med.Chem. 17 7457 PMID: 19800804

If you know of a relevant reference for H2L5186303, please let us know.

按标靶查看相关产品

Lysophosphatidic Acid Receptors

关键词: H2L5186303, H2L5186303 supplier, lysophosphatidic, acid, 2, receptors, LPA2, antagonists, Lysophosphatidic, Acid, Receptors, 4878, Tocris Bioscience

6 篇 H2L5186303 的引用文献

引用文献是使用了 Tocris 产品的出版物。 H2L5186303 的部分引用包括：

Wu et al (2015) Mechanosensitive PPAP2B Regulates Endothelial Responses to Atherorelevant Hemodynamic Forces. PLoS One 117 e41 PMID: 26034042

Yoshihiro et al (2021) Lysophosphatidic acid induces thrombospondin-1 production in primary cultured rat cortical astrocytes. J Neurochem 158 849-864 PMID: 33118159

Shigeru et al (2022) Lysophosphatidic Acid Promotes the Expansion of Cancer Stem Cells via TRPC3 Channels in Triple-Negative Breast Cancer. Int J Mol Sci 23 PMID: 35216080

Paul et al (2020) P130Cas/bcar1 mediates zebrafish caudal vein plexus angiogenesis. Sci Rep 10 15589 PMID: 32973180

Volden et al (2016) Mammary Adipose Tissue-Derived Lysophospholipids Promote Estrogen Receptor-Negative Mammary Epithelial Cell Proliferation. Cancer Prev Res (Phila) 9 367 PMID: 26862086

Robert et al (2023) The lysophosphatidic acid-regulated signal transduction network in ovarian cancer cells and its role in actomyosin dynamics, cell migration and entosis. Theranostics 13 1921-1948 PMID: 37064875

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Works as a negative control for LPA effects in culture..

By Anonymous on 11/18/2018

分析类型： In Vivo

种属： Mouse

细胞系/组织： primary mammary epithelium

Mouse Mammary epithelial cells were used in a standard mammosphere generating assay in a serum-free (B27 supplement), non-adherent condition. LPA or LPA antagonist (H2L5186303) were added to media and the number of spheres were counted after 6 days of culture. Results showed that 10 uM of the antagonist ameliorated most of the LPA-induced suppression, but did not fully neutralize LPA effects. Of two tested LPA inhibitors (products #4878, #5913), this was less effective by a small margin.

该领域的文献

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*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。

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