HBX 41108

Name: HBX 41108
Brand: Tocris Bioscience
SKU: 4285
Rating: 5 (1 reviews)

Cat. No. 4285 6 篇引用文献 1 条评论提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Selective USP7 inhibitor

化学名： 7-Chloro-9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile

纯度： ≥98% (HPLC)

说明书

引用文献 (6)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for HBX 41108

HBX 41108 is an inhibitor of ubiquitin-specific protease (USP) 7 activity (IC₅₀ = 424 nM). Displays uncompetitive inhibition. Also inhibits USP7-mediated p53 deubiquitination (IC₅₀ = 0.8 μM). Stabilizes p53 and inhibits cancer cell growth; induces p53-dependent apoptosis in p53 wild type and null isogenic cancer cell lines.

许可信息

Sold for research use only under patent license from Hybrigenics S.A.

技术数据 for HBX 41108

分子量	266.64
公式	C₁₃H₃ClN₄O
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	924296-39-9
PubChem ID	16065773
InChI Key	BIGPXXAUSQLTQR-UHFFFAOYSA-N
Smiles	O=C2C1=CC(Cl)=CC=C1C3=C2N=C(C#N)C(C#N)=N3

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for HBX 41108

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
溶解性	DMSO	26.66	100

制备储备液 for HBX 41108

以下数据基于产品分子量 266.64。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.75 mL	18.75 mL	37.5 mL
5 mM	0.75 mL	3.75 mL	7.5 mL
10 mM	0.38 mL	1.88 mL	3.75 mL
50 mM	0.08 mL	0.38 mL	0.75 mL

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产品说明书 for HBX 41108

分析证书/产品说明书

化学品安全技术说明书

参考文献 for HBX 41108

参考文献是支持产品生物活性的出版物。

Colland et al (2009) Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells. Mol.Cancer Ther. 8 2286 PMID: 19671755

Colombo et al (2010) Synthesis and biological evaluation of 9-oxo-9H-indeno[1,2-b]pyrazine-2,3-dicarbonitrile analogues as potential inhibitors of deubiquitinating enzymes. ChemMedChem 5 552 PMID: 20186914

If you know of a relevant reference for HBX 41108, please let us know.

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