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Submit ReviewHelianorphin-19
说明： Potent and selective G protein-biased κ opioid receptor (KOR) agonist
纯度： ≥95% (HPLC)
生物活性 for Helianorphin-19
Helianorphin-19 is a high affinity, potent and selective G protein-biased κ-opioid receptor (KOR) agonist (Ki = 25 nM; EC50 = 45 nM). Helianorphin-19 exhibits approximately 200-fold selectivity for KOR over μ and δ-opioid receptors. In vivo Helianorphin-19 shows potent peripheral analgesic efficacy in a mouse model of visceral pain without affecting motor coordination/sedation.
技术数据 for Helianorphin-19
| 分子量 | 1790.21 |
| 公式 | C81H132N26O16S2 |
| 序列 |
CYGGFLRRCIRPKLK (Modifications: Cyclic peptide, Disulfide bridge: 1-9] |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 2883653-86-7 |
| InChI Key | WEJHFJXWIBZZTQ-AHUOXLFJSA-N |
| Smiles | O=C(N[C@@H](CC1=CC=C(C=C1)O)C(NCC(NCC(N[C@@H](CC2=CC=CC=C2)C(N[C@@H](CC(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@H]3CCCNC(N)=N)=O)=O)=O)=O)=O)=O)[C@H](CSSC[C@@H](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N4[C@@H](CCC4)C(N[C@@H](CCCCN)C(N[C@@H](CC(C)C)C(N[C@H]5CCCCN)=O)=O)=O)=O)=O)=O)NC3=O)NC5=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Helianorphin-19
| 溶解性 | Soluble to 2 mg/ml in water |
产品说明书 for Helianorphin-19
参考文献 for Helianorphin-19
参考文献是支持产品生物活性的出版物。
Muratspahić et al (2021) Design of a stable cyclic peptide analgesic derived from sunflower seeds that targets the κ-opioid receptor for the treatment of chronic abdominal pain. J.Med.Chem. 64 9042 PMID: 34162205
If you know of a relevant reference for Helianorphin-19, please let us know.
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关键词: Helianorphin-19, Helianorphin-19 supplier, activates, opioid, kappa-opioid, agonists, agonism, KOP, Receptors, KOR, potent, selective, Kappa, Opioid, 7541, Tocris Bioscience
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