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HEMADO

Cat. No. 1579 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： High affinity selective A3 agonist
化学名： 2-(1-Hexynyl)-N-methyladenosine
纯度： ≥99% (HPLC)
说明书
引用文献 (2)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for HEMADO

HEMADO is a high affinity and selective adenosine A3 receptor agonist (Ki values are 1.1, 327, 1230 and > 30,000 nM for human A3, A1, A2A and A2B receptors respectively).

化合物库 for HEMADO

HEMADO is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for HEMADO

分子量 361.4
公式 C17H23N5O4
储存 Desiccate at +4°C
纯度 ≥99% (HPLC)
CAS Number 403842-38-6
PubChem ID 10981286
InChI Key KOCIMZNSNPOGOP-IWCJZZDYSA-N
Smiles O[C@@H]1[C@@H](CO)O[C@@H](N(C=N3)C2=C3C(NC)=NC(C#CCCCC)=N2)[C@@H]1O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for HEMADO

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
ethanol 36.14 100
DMSO 36.14 100

制备储备液 for HEMADO

以下数据基于产品分子量 361.4。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.77 mL 13.84 mL 27.67 mL
5 mM 0.55 mL 2.77 mL 5.53 mL
10 mM 0.28 mL 1.38 mL 2.77 mL
50 mM 0.06 mL 0.28 mL 0.55 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for HEMADO

参考文献是支持产品生物活性的出版物。

Klotz et al (2006) [3H]HEMADO- a novel tritated agonist selective for the human adenosine A3-receptor. Eur.J.Pharmacol. 556 14 PMID: 17126322

Volpini et al (2002) N6-Alkyl-2-alkynyl derivatives of adenosine as potent and selective agonists at the human adenosine A3 receptor and a starting point for searching A2B ligands J.Med.Chem. 45 3271 PMID: 12109910

If you know of a relevant reference for HEMADO, please let us know.

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关键词: HEMADO, HEMADO supplier, High, affinity, selective, A3, agonists, Receptors, adenosines, Adenosine, 1579, Tocris Bioscience

2 篇 HEMADO 的引用文献

引用文献是使用了 Tocris 产品的出版物。 HEMADO 的部分引用包括：

Stoddart et al (2012) Fragment screening at adenosine-A(3) receptors in living cells using a fluorescence-based binding assay. Chem Biol 19 1105 PMID: 22999879

Gomez et al (2011) Disparity in FcηRI-induced degranulation of primary human lung and skin mast cells exposed to adenosine. Mol Cell Proteomics 31 479 PMID: 21437670

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