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说明： Endogenous and selective NK1 agonist
生物活性 for Hemokinin 1 (human)
Hemokinin 1 (human) is an endogenous substance P homolog that is a selective agonist at the tachykinin NK1 receptor (IC50 values are 1.8, 370 and 480 nM for NK1, NK3 and NK2 receptors respectively). Has proliferative and antiapoptotic actions on B-cells in vitro and is antihypertensive in vivo.
技术数据 for Hemokinin 1 (human)
| 分子量 | 1185.4 |
| 公式 | C54H84N14O14S |
| 序列 |
TGKASQFFGLM (Modifications: Met- 11= C-terminal amide) |
| 储存 | Desiccate at -20°C |
| CAS Number | 491851-53-7 |
| PubChem ID | 71311766 |
| InChI Key | NYBLUYYRUFKGTB-XJCFQSCISA-N |
| Smiles | [H]N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Hemokinin 1 (human)
参考文献 for Hemokinin 1 (human)
参考文献是支持产品生物活性的出版物。
Bellucci et al (2002) Pharmacological profile of the novel mammalian tachykinin hemokinin 1. Br.J.Pharmacol. 135 266 PMID: 11786503
Kurtz et al (2002) Identification, localization and receptor characterization of novel mammalian substance P-like peptides. Gene 296 205 PMID: 12383518
Zhang et al (2000) Hemokinin is a hematopoietic-specific tachykinin that regulates B lymphopoiesis. Nature Immunol. 1 392
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关键词: Hemokinin 1 (human), Hemokinin 1 (human) supplier, Endogenous, selective, NK1, agonists, Tachykinin, Receptors, Neurokinin, Hemokinin1, (human), Receptor, 2576, Tocris Bioscience
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