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Submit ReviewHemopressin (rat)
说明： Selective CB1 inverse agonist
生物活性 for Hemopressin (rat)
Hemopressin (rat) is a bioactive endogenous peptide substrate for endopeptidase 24.15 (ep24.15), neurolysin (ep24.16) and ACE. Ki values are 27.76, 3.43 and 1.87 μM respectively. Potent hypotensive in vivo. Also acts as a selective CB1 receptor inverse agonist. Displays antinociceptive activity and induces hypophagia in vivo.
技术数据 for Hemopressin (rat)
| 分子量 | 1088.27 |
| 公式 | C53H77N13O12 |
| 序列 | PVNFKFLSH |
| 储存 | Desiccate at -20°C |
| CAS Number | 568588-77-2 |
| PubChem ID | 44560117 |
| InChI Key | DUTLYPZZJJBEAJ-QISMNGAHSA-N |
| Smiles | [H]N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC1=CNC=N1)C(O)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for Hemopressin (rat)
参考文献 for Hemopressin (rat)
参考文献是支持产品生物活性的出版物。
Heimann et al (2007) Hemopressin is an inverse agonist of CB1 cannabinoid receptors. Proc.Natl.Acad.Sci.U.S.A. 104 20588 PMID: 18077343
Rioli et al (2003) Novel natural peptide substrates for endopeptidase 24.15, neurolysin, and angiotensin-converting enzyme. J.Biol.Chem. 278 8547 PMID: 12500972
Todd et al (2010) The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice. J.Neurosci. 30 7369 PMID: 20505104
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关键词: Hemopressin (rat), Hemopressin (rat) supplier, Bioactive, endopeptidase, 2415, neurolysin, ACE, Angiotensin-Converting, Enzyme, Proteinases, Proteases, Substrates, activators, cannabinoids, receptors, CB1, inverse, agonists, antagonists, cb1r, /, Activators, Other, Receptors, 1764, Tocris Bioscience
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