HLM 006474

Name: HLM 006474
Brand: Tocris Bioscience
SKU: 5283

Cat. No. 5283 1 次引用提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

5283 has been discontinued.

View all Other Transcription Factors products.

说明： E2F transcription factor inhibitor

化学名： 7-[(4-Ethoxy-3-methylphenyl)(2-pyridinylamino)methyl]-2-methyl-8-quinolinol

纯度： ≥98% (HPLC)

说明书

引用文献 (1)

生物活性技术数据说明书参考文献

生物活性 for HLM 006474

HLM 006474 is an E2F transcription factor inhibitor; inhibits E2F DNA binding activity. Inhibits E2F4 DNA binding and reduces E2F4 protein levels in A375 melanoma cells. Induces apoptosis of A375 and MDA-MB-231 breast cancer cells. Inhibits A375 proliferation and invasion in a three dimensional skin model of A375 invasion. Also attenuates human embryonic stem cell proliferation.

技术数据 for HLM 006474

分子量	399.48
公式	C₂₅H₂₅N₃O₂
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	353519-63-8
PubChem ID	2895500
InChI Key	CYNZBLNMIJNBSF-UHFFFAOYSA-N
Smiles	CC1=C(OCC)C=CC(C(C3=C(O)C(N=C(C)C=C4)=C4C=C3)NC2=NC=CC=C2)=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

产品说明书 for HLM 006474

分析证书/产品说明书

化学品安全技术说明书

参考文献 for HLM 006474

参考文献是支持产品生物活性的出版物。

Ma et al (2008) A small-molecule E2F inhibitor blocks growth in a melanoma culture model. Cancer Res. 68 6292 PMID: 18676853

Conklin et al (2012) The RB family is required for the self-renewal and survival of human embryonic stem cells. Nat.Commun. 3 1244 PMID: 23212373

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