Honokiol

Cat. No. 4590 2 篇引用文献提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Pricing	Availability		Qty

说明： Blocks NF-κB activation; also anti-inflammatory and antioxidant

化学名： 5,3'-Diallyl-2,4'-dihydroxybiphenyl

纯度： ≥98% (HPLC)

引用文献 (2)

通路 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Honokiol

Honokiol is an anti-inflammatory, antioxidant, antitumor and antiangiogenic agent. Blocks NF-κB activation by a variety of stimuli, including TNF and okadaic acid. Shown to scavenge superoxide and peroxyl radicals. Also inhibits a variety of inflammatory responses. Reverses cardiac hypertrophy in mice via SIRT3 activation.

技术数据 for Honokiol

分子量	266.33
公式	C₁₈H₁₈O₂
储存	Store at +4°C
纯度	≥98% (HPLC)
CAS Number	35354-74-6
PubChem ID	72303
InChI Key	FVYXIJYOAGAUQK-UHFFFAOYSA-N
Smiles	OC1=C(C2=CC(CC=C)=C(O)C=C2)C=C(CC=C)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Honokiol

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	26.63	100
	ethanol	26.63	100

制备储备液 for Honokiol

以下数据基于产品分子量 266.33。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.75 mL	18.77 mL	37.55 mL
5 mM	0.75 mL	3.75 mL	7.51 mL
10 mM	0.38 mL	1.88 mL	3.75 mL
50 mM	0.08 mL	0.38 mL	0.75 mL

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产品说明书 for Honokiol

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Honokiol

参考文献是支持产品生物活性的出版物。

Kim and Cho (2008) Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression. Acta Pharmacol.Sinica 29 113 PMID: 18158873

Dikalov et al (2008) Honokiol is a potent scavenger of superoxide and peroxyl radicals. Biochem.Pharmacol. 76 589 PMID: 18640101

Ahn et al (2006) Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-κB activation pathway. Mol.Cancer Res. 4 621 PMID: 16966432

Bai et al (2003) Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J.Biol.Chem. 278 35501 PMID: 12816951

Pillai et al (2015) Nat.Commun. 6 6656 PMID: 25871545

If you know of a relevant reference for Honokiol, please let us know.

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关键词: Honokiol, Honokiol supplier, anti-inflammatories, antioxidants, antitumor, antiangiogenics, nf-kb, nf-kappa, b, nf-κb, inhibitors, inhibits, NF-kB/IkB, Antioxidants, Class, III, HDACs, (Sirtuins), 4590, Tocris Bioscience

2 篇 Honokiol 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Honokiol 的部分引用包括：

Melitta et al (2022) Mitochondrial and Neuronal Dysfunctions in L1 Mutant Mice. Int J Mol Sci 23 PMID: 35457156

Xu et al (2017) Trimebutine, a small molecule mimetic agonist of adhesion molecule L1, contributes to functional recovery after spinal cord injury in mice. Dis Model Mech 10 1117 PMID: 28714852

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Pathways for Honokiol

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.