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Honokiol

Cat. No. 4590 2 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

Discontinued Product

4590 has been discontinued.

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说明： Blocks NF-κB activation; also anti-inflammatory and antioxidant
化学名： 5,3'-Diallyl-2,4'-dihydroxybiphenyl
纯度： ≥98% (HPLC)
说明书
引用文献 (2)
评论
通路 (1)
生物活性 技术数据 说明书 参考文献

生物活性 for Honokiol

Honokiol is an anti-inflammatory, antioxidant, antitumor and antiangiogenic agent. Blocks NF-κB activation by a variety of stimuli, including TNF and okadaic acid. Shown to scavenge superoxide and peroxyl radicals. Also inhibits a variety of inflammatory responses. Reverses cardiac hypertrophy in mice via SIRT3 activation.

技术数据 for Honokiol

分子量 266.33
公式 C18H18O2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 35354-74-6
PubChem ID 72303
InChI Key FVYXIJYOAGAUQK-UHFFFAOYSA-N
Smiles OC1=C(C2=CC(CC=C)=C(O)C=C2)C=C(CC=C)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

参考文献 for Honokiol

参考文献是支持产品生物活性的出版物。

Kim and Cho (2008) Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression. Acta Pharmacol.Sinica 29 113 PMID: 18158873

Dikalov et al (2008) Honokiol is a potent scavenger of superoxide and peroxyl radicals. Biochem.Pharmacol. 76 589 PMID: 18640101

Ahn et al (2006) Honokiol potentiates apoptosis, suppresses osteoclastogenesis, and inhibits invasion through modulation of nuclear factor-κB activation pathway. Mol.Cancer Res. 4 621 PMID: 16966432

Bai et al (2003) Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. J.Biol.Chem. 278 35501 PMID: 12816951

Pillai et al (2015) Nat.Commun. 6 6656 PMID: 25871545

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关键词: Honokiol, Honokiol supplier, anti-inflammatories, antioxidants, antitumor, antiangiogenics, nf-kb, nf-kappa, b, nf-κb, inhibitors, inhibits, NF-kB/IkB, Antioxidants, Class, III, HDACs, (Sirtuins), 4590, Tocris Bioscience

2 篇 Honokiol 的引用文献

引用文献是使用了 Tocris 产品的出版物。 Honokiol 的部分引用包括：

Xu et al (2017) Trimebutine, a small molecule mimetic agonist of adhesion molecule L1, contributes to functional recovery after spinal cord injury in mice. Dis Model Mech 10 1117 PMID: 28714852

Melitta et al (2022) Mitochondrial and Neuronal Dysfunctions in L1 Mutant Mice. Int J Mol Sci 23 PMID: 35457156

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Pathways for Honokiol

NF-κB Signaling Pathway

NF-κB Signaling Pathway

NF-κB signaling plays an important role in inflammation, the innate and adaptive immune response and stress. Dysregulated signaling can occur in inflammatory and autoimmune diseases.