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Submit ReviewHU 211
说明： NMDA receptor antagonist; also NF-κB inhibitor
别名： Dexanabinol
化学名： (6aS,10aS)-3-(1,1-Dimethylheptyl)-6a,7,10,10a-tetrahydro-1-hydroxy-6,6-dimethyl-6H-dibenzo[b,d]pyran-9-methanol
纯度： ≥97% (HPLC)
生物活性 for HU 211
HU 211 is a NMDA antagonist (IC50 = 11 μM for inhibition of [3H]MK-801 binding to rat forebrain membranes). Protects against NMDA- and quisqualate-induced neurotoxicity (EC50 = 3.8 μM) and enhances dopamine D1 receptor activity. Inhibits NF-κB, reducing TNF-α, IL-6 and nitric oxide production, and acts as a free radical scavenger. Exhibits beneficial effects in experimental models of multiple sclerosis, bacterial meningitis, septic shock, epilepsy, and traumatic and ischemic brain injury. Brain penetrant.
技术数据 for HU 211
| 分子量 | 386.57 |
| 公式 | C25H38O3 |
| 储存 | Store at -20°C |
| 纯度 | ≥97% (HPLC) |
| CAS Number | 112924-45-5 |
| PubChem ID | 107778 |
| InChI Key | SSQJFGMEZBFMNV-PMACEKPBSA-N |
| Smiles | CCCCCCC(C)(C)C1=CC(O)=C([C@]2([H])[C@](C(C)(C)O3)([H])CC=C(CO)C2)C3=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
产品说明书 for HU 211
参考文献 for HU 211
参考文献是支持产品生物活性的出版物。
Eshhar et al (1993) HU-211, a non-psychotropic cannabinoid, rescues cortical neurones from excitatory amino acid toxicity in culture. Neuroreport 5 237 PMID: 8298080
Striem et al (1997) Interaction of dexanabinol (HU-211), a novel NMDA receptor antagonist, with the DArgic system. Eur.J.Pharmacol. 338 205 PMID: 9424014
Gallily et al (1997) Protection against septic shock and suppression of tumor necrosis factor α and nitric oxide production by dexanabinol (HU-211), a nonpsychotropic cannabinoid. J.Pharmacol.Exp.Ther. 283 918 PMID: 9353414
Juttler et al (2004) The cannabinoid dexanabinol is an inhibitor of the nuclear factor kappa B (NF-κB). Neuropharmacology 47 580 PMID: 15380375
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关键词: HU 211, HU 211 supplier, NF-κB, NF-kappaB, NF-kB, inhibitors, inhibits, decreases, TNF-α, TNF-alpha, IL-6, NO, production, NMDA, antagonists, receptors, Nuclear, Factor, Kappa, B, Cytokine, Signaling, Signalling, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, HU211, Dexanabinol, NF-kB/IkB, 2861, Tocris Bioscience
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该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
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