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Submit ReviewHydrocortisone
说明： Adrenal glucocorticoid; immunosuppressant
化学名： 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione
纯度： ≥98% (HPLC)
生物活性 for Hydrocortisone
Hydrocortisone is an adrenal glucocorticoid released in the stress response. Increases glucose production by gluconeogenesis. Immunosuppressant and antidiuretic hormone. Used in protocols to generate retinal pigment epithelial (RPE) cells from PSCs.
化合物库 for Hydrocortisone
Hydrocortisone is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. 了解 Tocris 化合物库的更多信息。
技术数据 for Hydrocortisone
| 分子量 | 362.46 |
| 公式 | C21H30O5 |
| 储存 | Store at RT |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 50-23-7 |
| PubChem ID | 5754 |
| InChI Key | JYGXADMDTFJGBT-VWUMJDOOSA-N |
| Smiles | O=C1CC[C@@]2(C)C(CC[C@]3([H])[C@@]([H])2[C@@H](O)C[C@@]4(C)[C@]([H])3CC[C@@](O)4[C@@](CO)=O)=C1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for Hydrocortisone
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 36.25 | 100 | |
| ethanol | 9.06 | 25 |
制备储备液 for Hydrocortisone
以下数据基于产品分子量 362.46。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.76 mL | 13.79 mL | 27.59 mL |
| 5 mM | 0.55 mL | 2.76 mL | 5.52 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.76 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
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产品说明书 for Hydrocortisone
参考文献 for Hydrocortisone
参考文献是支持产品生物活性的出版物。
Khani and Tayek (2001) Cortisol increases gluconeogenesis in humans; its role in the metabolic syndrome. Clin.Sci.(Lond) 101 739 PMID: 11724664
Surendran et al (2022) An improved protocol for generation and characterization of human-induced pluripotent stem cell-derived retinal pigment epithelium cells STAR Protoc. 3 101803 PMID: 36386870
If you know of a relevant reference for Hydrocortisone, please let us know.
关键词: Hydrocortisone, Hydrocortisone supplier, glucocorticoids, antiinflammatory, stress, induces, inducers, gluconeogenesis, adrenal, gland, 11b,17a,21-Trihydroxypregn-4-ene-3,20-dione, Glucocorticoid, Receptor, Immunosuppressants, Retinal, Stem, Cells, 4093, Tocris Bioscience
4 篇 Hydrocortisone 的引用文献
引用文献是使用了 Tocris 产品的出版物。 Hydrocortisone 的部分引用包括：
Frost et al (2017) The Use of DQ-BSA to Monitor the Turnover of Autophagy-Associated Cargo. Methods Enzymol 587 43 PMID: 28253971
Georges et al (2022) Polyploid giant cancer cells, EZH2 and Myc upregulation in mammary epithelial cells infected with high-risk human cytomegalovirus. EBioMedicine 80 104056 PMID: 35596973
Srinivasan et al (2018) Androgen receptor expression reduces stemness characteristics of prostate cancer cells (PC3) by repression of CD44 and SOX2. J Cell Biochem PMID: 30206982
Paul F et al (2021) Cell Populations Expressing Stemness-Associated Markers in Lung Adenocarcinoma. Life (Basel) 11 PMID: 34685477
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Hydrocortisone 的评论
平均评分: 4 (Based on 1 Review.)
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cell culture.
By
Irving Garcia on 11/19/2020
分析类型： In Vitro
种属： Human
细胞系/组织： ES cells
Used before always use from Tocris. Always works well in cell culture.
该领域的文献
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*请注意，Tocris 仅会向正规科研企业/机构地址发送文献。
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.