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I 432

Cat. No. 7292 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： TMPRSS2 Inhibitor
化学名： 3-[(2S)-3-[4-(2-Aminoethyl)-1-piperidinyl]-2-[[(2',4'-dichloro[1,1'-biphenyl]-3-yl)sulfonyl]amino]-3-oxopropyl]benzenecarboximidamide ditrifluoroacetate
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for I 432

I 432 is a TMPRSS2 (transmembrane serine proteinase 2) inhibitor (Ki =0.9 nM). It blocks influenza virus propagation in airway epithelial cells. In IPEC-J2 pig jejunal epithelial cells, I 432 (50 μM) inhibits TMPRSS2 without affecting cell viability after 48 h treatment.

技术数据 for I 432

分子量 830.62
公式 C29H33Cl2N5O3S.2CF3CO2H
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 1268874-09-4
InChI Key HCTPOLRWOSFUBB-LPCSYZHESA-N
Smiles NCCC1CCN(C([C@@H](NS(=O)(C2=CC=CC(C3=C(C=C(C=C3)Cl)Cl)=C2)=O)CC4=CC(C(N)=N)=CC=C4)=O)CC1.OC(C(F)(F)F)=O.OC(C(F)(F)F)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for I 432

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 83.06 100
ethanol 83.06 100

制备储备液 for I 432

以下数据基于产品分子量 830.62。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.2 mL 6.02 mL 12.04 mL
5 mM 0.24 mL 1.2 mL 2.41 mL
10 mM 0.12 mL 0.6 mL 1.2 mL
50 mM 0.02 mL 0.12 mL 0.24 mL

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参考文献 for I 432

参考文献是支持产品生物活性的出版物。

Meyer et al (2013) Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation. Biochem J. 452 331 PMID: 23527573

Pászti-Gere et al (2016) In vitro characterization of TMPRSS2 inhibition in IPEC-J2 cells. J.Enzyme Inhib.Med.Chem. 31 123 PMID: 27277342

Alexander et al (2020) A rational roadmap for SARS-CoV-2/COVID-19 pharmacotherapeutic research and development: IUPHAR Review 29. Br.J.Pharmacol. 177 4942 PMID: 32358833

If you know of a relevant reference for I 432, please let us know.

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关键词: I 432, I 432 supplier, I432, inhibitors, inhibits, TMPRSS2, transmembrane, serine, proteinase, 2, influenza, viruses, Influenza, Viruses, 7292, Tocris Bioscience

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