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说明： PDE inhibitor (non-selective)
化学名： 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione
纯度： ≥98% (HPLC)
生物活性 for IBMX
IBMX is a phosphodiesterase inhibitor (IC50 values are 13, 18, 19, 32 and 50 μM for PDE4, PDE3, PDE1, PDE5 and PDE2 respectively). Suppresses α-adrenoceptor-mediated 5-HT release from neuroendocrine epithelial cells (IC50 = 1.3 μM). Facilitates differentiation of neural progenitor cells in vitro.
化合物库 for IBMX
IBMX is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for IBMX
| 分子量 | 222.24 |
| 公式 | C10H14N4O2 |
| 储存 | Store at +4°C |
| 纯度 | ≥98% (HPLC) |
| CAS Number | 28822-58-4 |
| PubChem ID | 3758 |
| InChI Key | APIXJSLKIYYUKG-UHFFFAOYSA-N |
| Smiles | O=C1C2=C(N=CN2)N(CC(C)C)C(N1C)=O |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for IBMX
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 16.67 | 75 |
制备储备液 for IBMX
以下数据基于产品分子量 222.24。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.75 mM | 6 mL | 30 mL | 60 mL |
| 3.75 mM | 1.2 mL | 6 mL | 12 mL |
| 7.5 mM | 0.6 mL | 3 mL | 6 mL |
| 37.5 mM | 0.12 mL | 0.6 mL | 1.2 mL |
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产品说明书 for IBMX
参考文献 for IBMX
参考文献是支持产品生物活性的出版物。
Freitag et al (1998) Phosphodiesterase inhibitors suppress α2-adrenoceptor-mediated 5-hydroxytryptamine release from tracheae of newborn rabbits. Eur.J.Pharmacol. 354 67 PMID: 9726632
Lepski et al (2013) cAMP promotes the differentiation of neural progenitor cells in vitro via modulation of voltage-gated calcium channels. Front.Cell Neurosci. 7 155 PMID: 24065885
If you know of a relevant reference for IBMX, please let us know.
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关键词: IBMX, IBMX supplier, PDE, inhibitors, inhibits, non-selective, Phosphodiesterases, Neural, Stem, Cells, 2845, Tocris Bioscience
18 篇 IBMX 的引用文献
引用文献是使用了 Tocris 产品的出版物。 IBMX 的部分引用包括：
Havekes et al (2016) Compartmentalized PDE4A5 Signaling Impairs Hippocampal Synaptic Plasticity and Long-Term Memory. J Neurosci 36 8936 PMID: 27559174
Cuppoletti et al (2014) Differentiation between human ClC-2 and CFTR Cl- channels with pharmacological agents. Am J Physiol Cell Physiol 307 C479 PMID: 25009109
Jewell et al (2019) GPCR signaling inhibits mTORC1 via PKA phosphorylation of Raptor. Elife 8 PMID: 31112131
An et al (2019) Stem cell-derived cranial and spinal motor neurons reveal proteostatic differences between ALS resistant and sensitive motor neurons. Elife 8 PMID: 31157617
Cooke et al (2015) Morphine-induced internalization of the L83I mutant of the rat μ-opioid receptor. Biomed Res Int 172 593 PMID: 24697554
Ghosh et al (2015) The interplay between cyclic AMP, MAPK, and NF-κB pathways in response to proinflammatory signals in microglia. Eneuro 2015 308461 PMID: 25722974
Polito et al (2015) Selective Effects of PDE10A Inhibitors on Striatopallidal Neurons Require Phosphatase Inhibition by DARPP-32(1,2,3). PLoS One 2 PMID: 26465004
Merino et al (2015) Glucagon Increases Beating Rate but Not Contractility in Rat Right Atrium. Comparison with isoprote. Am J Physiol Lung Cell Mol Physiol 10 e0132884 PMID: 26222156
Hook et al (2012) DArgic modulation of ganglion-cell photoreceptors in rat. Br J Pharmacol 35 507 PMID: 22304466
Foster et al (2015) Low-glucose enhances keratocyte-characteristic phenotype from corneal stromal cells in serum-free conditions. Sci Rep 5 10839 PMID: 26039975
Elliott et al (2015) Somatostatin and Ins mediate glucose-inhibited glucagon secretion in the pancreatic α-cell by lowering cAMP. Am J Physiol Endocrinol Metab 308 E130 PMID: 25406263
Patra et al (2018) Mutant GNAS drives pancreatic tumourigenesis by inducing PKA-mediated SIK suppression and reprogramming lipid metabolism. Nat Cell Biol 20 811 PMID: 29941929
Lundegaard et al (2015) MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish. Chem Biol 22 1335 PMID: 26388333
Cuppoletti et al (2013) Methadone but not mor. inhibits lubiprostone-stimulated Cl- currents in T84 intestinal cells and recombinant human ClC-2, but not CFTR Cl- currents. Cell Biochem Biophys 66 53 PMID: 22918821
Jazayeri (2017) Crystal structure of the GLP-1 receptor bound to a peptide agonist. Nature 546 254 PMID: 28562585
Burdyga et al (2018) Phosphatases control PKA-dependent functional microdomains at the outer mitochondrial membrane. Proc Natl Acad Sci U S A. 115 E6497 PMID: 29941564
Demeautis et al (2017) Multiplexing PKA and ERK12 kinases FRET biosensors in living cells using single excitation wavelength dual colour FLIM. Sci Rep 7 41026 PMID: 28106114
Hernández-Cascales (2017) Resveratrol enhances the inotropic effect but inhibits the proarrhythmic effect of sympathomimetic agents in rat myocardium. PeerJ 5 e3113 PMID: 28382232
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IBMX 的评论
平均评分: 5 (Based on 1 Review.)
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Rapid inhibition of PDE in acute brain slices.
By
Anonymous on 01/04/2018
分析类型： Ex Vivo
种属： Mouse
细胞系/组织： acute brain slice
Exogenous application of IBMX on brain slices
Effect is observed within minutes.