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Ibudilast

Cat. No. 1694 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： PDE inhibitor (non-selective)
别名： KC-404
化学名： 2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl]-1-propanone
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for Ibudilast

Ibudilast is a phosphodiesterase inhibitor (IC50 values are 53, 35, 48, 12 and 10 μM for PDE Ia, II, III, IV and V respectively). Inhibits platelet aggregation and is an orally-active cerebral vasodilator, bronchodilator and antiallergic agent.

化合物库 for Ibudilast

Ibudilast is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Ibudilast

分子量 230.31
公式 C14H18N2O
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 50847-11-5
PubChem ID 3671
InChI Key ZJVFLBOZORBYFE-UHFFFAOYSA-N
Smiles CC(C)C(=O)C1=C2C=CC=CN2N=C1C(C)C

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Ibudilast

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 23.03 100
ethanol 23.03 100

制备储备液 for Ibudilast

以下数据基于产品分子量 230.31。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 4.34 mL 21.71 mL 43.42 mL
5 mM 0.87 mL 4.34 mL 8.68 mL
10 mM 0.43 mL 2.17 mL 4.34 mL
50 mM 0.09 mL 0.43 mL 0.87 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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参考文献 for Ibudilast

参考文献是支持产品生物活性的出版物。

Kishi et al (2001) Ibudilast: a non-selective PDE inhibitor with multiple actions on blood cells and the vascular wall. Cardiovasc.Drug Rev. 19 215 PMID: 11607039

Nishino et al (1983) KC-404: a potential anti-allergic agent with antagonistic action against slow reacting substance of anaphylaxis. Jpn.J.Pharmacol. 33 267 PMID: 6193303

Souness et al (1994) Possible role of cyclic AMP phosphodiesterases in the actions of ibudilast on eosinophil thromboxane generation and airways smooth muscle tone. Br.J.Pharmacol. 111 1081 PMID: 8032594

If you know of a relevant reference for Ibudilast, please let us know.

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关键词: Ibudilast, Ibudilast supplier, PDE, inhibitors, inhibits, non-selective, Phosphodiesterases, KC404, KC-404, 1694, Tocris Bioscience

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