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Submit ReviewICA 069673
说明： KV7.2/KV7.3 channel opener
化学名： N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
纯度： ≥99% (HPLC)
生物活性 for ICA 069673
ICA 069673 is a selective KV7.2/KV7.3 (KCNQ2/3) channel opener (EC50 = 0.69 μM). Exhibits 20-fold selectivity for KV7.2/KV7.3 over KV7.3/KV7.5, with no measurable activity over a panel of cardiac ion channels. Hyperpolarizes resting membrane potential and inhibits spontaneous action potentials in guinea pig detrusor muscle (DSM) isolated cells. Orally active in animal models of epilepsy.
化合物库 for ICA 069673
ICA 069673 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。
技术数据 for ICA 069673
| 分子量 | 269.63 |
| 公式 | C11H6ClF2N3O |
| 储存 | Store at RT |
| 纯度 | ≥99% (HPLC) |
| CAS Number | 582323-16-8 |
| PubChem ID | 10149311 |
| InChI Key | IIBSHMFXVWTQSJ-UHFFFAOYSA-N |
| Smiles | ClC1=NC=C(NC(C2=CC(F)=C(F)C=C2)=O)C=N1 |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for ICA 069673
| 溶剂 | 最高浓度 mg/mL | 最高浓度 mM | |
|---|---|---|---|
| 溶解性 | |||
| DMSO | 26.96 | 100 | |
| ethanol | 6.74 | 25 |
制备储备液 for ICA 069673
以下数据基于产品分子量 269.63。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 浓度/溶剂体积/质量 | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.71 mL | 18.54 mL | 37.09 mL |
| 5 mM | 0.74 mL | 3.71 mL | 7.42 mL |
| 10 mM | 0.37 mL | 1.85 mL | 3.71 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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产品说明书 for ICA 069673
参考文献 for ICA 069673
参考文献是支持产品生物活性的出版物。
Amato et al (2011) N-pyridyl and pyrimidine benzamides as KCNQ2/Q3 potassium channel openers for the treatment of epilepsy. ACS Med.Chem.Lett. 2 481 PMID: 24900334
Provence et al (2015) The novel Kv7.2/Kv7.3 channel opener ICA-069673 reveals subtype-specific functional roles in guinea pig detrusor smooth muscle excitability and contractility. J.Pharmacol.Exp.Ther. 354 290 PMID: 26087697
If you know of a relevant reference for ICA 069673, please let us know.
关键词: ICA 069673, ICA 069673 supplier, ICA069673, KCNQ2, KCNQ3, kv7.2, kv7.3, channel, opener, potassium, K+, voltage, gated, openers, Kv, Voltage-Gated, Potassium, Channels, 4305, Tocris Bioscience
3 篇 ICA 069673 的引用文献
引用文献是使用了 Tocris 产品的出版物。 ICA 069673 的部分引用包括：
Vicente-Baz et al (2016) Effects of novel subtype selective M-current activators on spinal reflexes in vitro: Comparison with retigabine. Neuropharmacology 109 131 PMID: 27263036
Radin et al (2024) Lucanthone, a potential PPT1 inhibitor, perturbs stemness, reduces tumor microtube formation and slows the growth of temozolomide-resistant gliomas in vivo. J.Pharmacol.Exp.Ther. PMID: 38296645
Brueggemann et al (2014) Differential activation of vascular smooth muscle Kv7.4, Kv7.5, and Kv7.4/7.5 channels by ML213 and ICA-069673. Mol.Pharmacol. 2014 330 PMID: 24944189
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ICA 069673 的评论
平均评分: 5 (Based on 1 Review.)
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ICA 069673 was used to study Kv channel opening on brain tissues of rodents.
By
Eleanor Baxter on 10/23/2018
分析类型： In Vitro
种属： Rat
ICA 069673 was used to study Kv channel opening on brain tissues of rodents. It shows variable but big % of channel opening.
