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ICA 110381

Cat. No. 4950 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： KV7.2/7.3 activator; displays anticonvulsant properties
化学名： 4-Chloro-N-(6-chloro-3-pyridinyl)benzamide
纯度： ≥98% (HPLC)
说明书
引用文献
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ICA 110381

ICA 110381 is a KV7.2/7.3 activator (EC50 = 0.38 μM). Decreases neuronal excitability in CA1 hippocampal neurons. Exhibits anticonvulsive properties in amygdala-kindled rats, a model for complex partial seizures.

化合物库 for ICA 110381

ICA 110381 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ICA 110381

分子量 267.11
公式 C12H8Cl2N2O
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 325457-99-6
PubChem ID 4314115
InChI Key FOYOGIUAMYSVIT-UHFFFAOYSA-N
Smiles O=C(NC2=CC=C(Cl)N=C2)C1=CC=C(Cl)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ICA 110381

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 26.71 100
ethanol 5.34 20

制备储备液 for ICA 110381

以下数据基于产品分子量 267.11。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 3.74 mL 18.72 mL 37.44 mL
5 mM 0.75 mL 3.74 mL 7.49 mL
10 mM 0.37 mL 1.87 mL 3.74 mL
50 mM 0.07 mL 0.37 mL 0.75 mL

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参考文献 for ICA 110381

参考文献是支持产品生物活性的出版物。

Amato et al (2011) N-Pyridyl and Pyrimidine Benzamides as KCNQ2/Q3 Potassium Channel Openers for the Treatment of Epilepsy. ACS Med.Chem.Lett. 2 481

Boehlen et al (2013) The new KCNQ2 activator 4-Chlor-N-(6-chlor-pyridin-3-yl)-benzamid displays anticonvulsant potential. Br.J.Pharmacol. 168 1182 PMID: 23176257

If you know of a relevant reference for ICA 110381, please let us know.

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关键词: ICA 110381, ICA 110381 supplier, ICA110381, KV7.2/7.3, KV7.2, KV7.3, KV7, KCNQ2, KCNQ3, KCNQ2/3, potassium, channels, epilepsy, seizures, anticonvulsive, antoconvulsant, excitability, neuronal, neurons, Voltage-Gated, Potassium, Channels, 4950, Tocris Bioscience

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