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ICA 121431

Cat. No. 5066 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
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说明： Potent and selective NaV1.3 and NaV1.1 channel blocker
化学名： α-Phenyl-N-[4-[(2-thiazolylamino)sulfonyl]phenyl]benzeneacetamide
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ICA 121431

ICA 121431 is a potent and selective inhibitor of human NaV1.3 and NaV1.1 channels (IC50 values are 13 and 23 nM respectively). Exhibits up to 1,000 fold selectivity against other TTX-sensitive or resistant sodium channels (IC50 values are >10 μM for human NaV1.5 and NaV1.8 channels). Interacts with an inhibitory interaction site distinct from those bound by TTX and local anesthetic-like modulators.

化合物库 for ICA 121431

ICA 121431 is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for ICA 121431

分子量 449.55
公式 C23H19N3O3S2
储存 Store at +4°C
纯度 ≥98% (HPLC)
CAS Number 313254-51-2
PubChem ID 998021
InChI Key URSQNPPONHUJDL-UHFFFAOYSA-N
Smiles O=S(C1=CC=C(NC(C(C4=CC=CC=C4)C3=CC=CC=C3)=O)C=C1)(NC2=NC=CS2)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ICA 121431

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 44.95 100

制备储备液 for ICA 121431

以下数据基于产品分子量 449.55。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 2.22 mL 11.12 mL 22.24 mL
5 mM 0.44 mL 2.22 mL 4.45 mL
10 mM 0.22 mL 1.11 mL 2.22 mL
50 mM 0.04 mL 0.22 mL 0.44 mL

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产品说明书 for ICA 121431

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for ICA 121431

参考文献是支持产品生物活性的出版物。

McCormack et al (2013) Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels. Proc.Natl.Acad.Sci. 110 2724 PMID: 23818614

If you know of a relevant reference for ICA 121431, please let us know.

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关键词: ICA 121431, ICA 121431 supplier, Selective, NaV, blockers, Sodium, Channels, voltage-gated, voltage-dependent, Na+, ICA121431, Voltage-gated, 5066, Tocris Bioscience

3 篇 ICA 121431 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ICA 121431 的部分引用包括：

Darik A et al (2022) NaV1.1 is essential for proprioceptive signaling and motor behaviors. Elife 11 PMID: 36278870

Kocmalova et al (2017) Control of Neurotransmission by NaV1.7 in Human, Guinea Pig, and Mouse Airway Parasympathetic Nerves. J Pharmacol Exp Ther 361 172 PMID: 28138042

Ellen A et al (2019) Tetrodotoxin-Sensitive Sodium Channels Mediate Action Potential Firing and Excitability in Menthol-Sensitive Vglut3-Lineage Sensory Neurons. J Neurosci 39 7086-7101 PMID: 31300524

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