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ICI 204,448 hydrochloride

Cat. No. 0822 1 次引用 1 条评论 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： κ agonist, acts peripherally
化学名： (RS)-[3-[1-[[(3,4-Dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]acetic acid hydrochloride
纯度： ≥98% (HPLC)
说明书
引用文献 (1)
评论 (1)
文献 (2)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for ICI 204,448 hydrochloride

ICI 204,448 hydrochloride is a peripherally acting κ agonist.

许可信息

Sold with the permission of AstraZeneca UK Ltd.

技术数据 for ICI 204,448 hydrochloride

分子量 501.84
公式 C23H26Cl2N2O4.HCl
储存 Store at RT
纯度 ≥98% (HPLC)
CAS Number 121264-04-8
PubChem ID 129407
InChI Key FNDGLVOYAQNQPE-UHFFFAOYSA-N
Smiles Cl.CN(C(CN1CCCC1)C1=CC(OCC(O)=O)=CC=C1)C(=O)CC1=CC(Cl)=C(Cl)C=C1

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for ICI 204,448 hydrochloride

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
DMSO 100

制备储备液 for ICI 204,448 hydrochloride

以下数据基于产品分子量 501.84。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.99 mL 9.96 mL 19.93 mL
5 mM 0.4 mL 1.99 mL 3.99 mL
10 mM 0.2 mL 1 mL 1.99 mL
50 mM 0.04 mL 0.2 mL 0.4 mL

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产品说明书 for ICI 204,448 hydrochloride

分析证书/产品说明书
选择另一批次：
化学品安全技术说明书

参考文献 for ICI 204,448 hydrochloride

参考文献是支持产品生物活性的出版物。

Keïta et al (1995) Antinociceptive effect of a κ-opioid receptor agonist that minimally crosses the blood-brain barrier (ICI 204448) in a rat model of mononeuropathy. Eur.J.Pharmacol. 277 275 PMID: 7493620

Shaw et al (1989) ICI-204,448: a κ-opioid agonist with limited access to the CNS. Br.J.Pharmacol. 96 986 PMID: 2568146

If you know of a relevant reference for ICI 204,448 hydrochloride, please let us know.

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关键词: ICI 204,448 hydrochloride, ICI 204,448 hydrochloride supplier, κ-opioid, kappa-opioid, agonists, peripherally, KOP, Receptors, OP2, ICI204448, hydrochloride, AstraZeneca, Kappa, Opioid, 0822, Tocris Bioscience

1 篇 ICI 204,448 hydrochloride 的引用文献

引用文献是使用了 Tocris 产品的出版物。 ICI 204,448 hydrochloride 的部分引用包括：

Butelman et al (2010) The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects. Psychopharmacology (Berl) 210 253 PMID: 20084367

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ICI 204,448 hydrochloride 的评论

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