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Submit ReviewIDR 1002
说明： Innate defence regulator peptide
纯度： ≥95% (HPLC)
生物活性 for IDR 1002
IDR 1002 is an innate defence regulator peptide. It reduces bacterial burden and inflammatory responses in murine models of sinusitis infection and bacterial acute lung infection. It inhibits LPS-induced NF-κB and COX-2 and induces the phosphorylation/activation of p38, ERK1/2, MSK1, and CREB.
技术数据 for IDR 1002
| 分子量 | 1652.06 |
| 公式 | C79H130N26O13 |
| 序列 |
VQRWLIVWRIRK Modifications: Lys-12; C-terminal amide) |
| 储存 | Store at -20°C |
| 纯度 | ≥95% (HPLC) |
| CAS Number | 1224095-25-3 |
| PubChem ID | 166603919 |
| InChI Key | SEBZWKNTKRJFDZ-BRVBZNILSA-N |
| Smiles | O=C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC1=CNC2=CC=CC=C12)C(N[C@@H](CC(C)C)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](C(C)C)C(N[C@@H](CC3=CNC4=CC=CC=C34)C(N[C@@H](CCCNC(N)=N)C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCCCN)C(N)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](C(C)C)N |
上方提供的技术数据仅供参考。批次相关数据请参见分析证书。
Tocris products are intended for laboratory research use only, unless stated otherwise.
溶解性数据 for IDR 1002
| 溶解性 | Soluble to 1 mg/ml in water |
产品说明书 for IDR 1002
参考文献 for IDR 1002
参考文献是支持产品生物活性的出版物。
Alford et al (2021) Murine model of sinusitis infection for screening antimicrobial and immunomodulatory therapies. Front.Cell.Infect.Microbiol. 11 621081 PMID: 33777834
Wuerth et al (2018) Characterization of host responses during pseudomonas aeruginosa acute infection in the lungs and blood and after treatment with the synthetic immunomodulatory peptide IDR-1002. Infect.Immun. 87 e00661 PMID: 30323028
Huante-Mendoza et al (2016) Peptide IDR-1002 inhibits NF-κB nuclear translocation by inhibition of IκBα degradation and activates p38/ERK1/2-MSK1-dependent CREB phosphorylation in macrophages stimulated with lipopolysaccharide. Front.Immunol. 7 533 PMID: 27933067
If you know of a relevant reference for IDR 1002, please let us know.
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关键词: IDR 1002, IDR 1002 supplier, IDR1002, antimicrobial, host-defense, peptides, inflammation, sinusitis, lung, infection, in, vivo, CREB, COX2, cytokines, IDR, innate, defence, response, peptide, p38, ERK, NF-kB/IkB, Cytokines, 7866, Tocris Bioscience
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