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INCB 3284 dimesylate

Cat. No. 4306 3 篇引用文献 提交评论 说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）
Pricing Availability   Qty
说明： Selective CCR2 antagonist
化学名： N-[2-[[(3R)-1-[trans-4-Hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide dimethanesulfonate
纯度： ≥98% (HPLC)
说明书
引用文献 (3)
评论
文献 (1)
生物活性 技术数据 溶解性 计算器 说明书 参考文献

生物活性 for INCB 3284 dimesylate

INCB 3284 dimesylate is a potent, selective hCCR2 antagonist. Exhibits potent antagonism against monocyte chemoattractant molecule binding to hCCR2 and chemotaxis activity (IC50 values are 3.7 and 4.7 nM respectively). Also displays weak hERG activity; inhibits the hERG potassium current (IC50 = 84μ M). Orally bioavailable.

化合物库 for INCB 3284 dimesylate

INCB 3284 dimesylate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen Antiviral Library. 了解 Tocris 化合物库的更多信息。

技术数据 for INCB 3284 dimesylate

分子量 712.76
公式 C26H31F3N4O4.2CH4O3S
储存 Store at -20°C
纯度 ≥98% (HPLC)
CAS Number 887401-93-6
PubChem ID 11679268
InChI Key PNPNUHKICDECDH-SEBNIYPMSA-N
Smiles O=C(NCC(N[C@@H]2CCN([C@H]3CC[C@](C4=CC=C(OC)N=C4)(O)CC3)C2)=O)C1=CC(C(F)(F)F)=CC=C1.CS(=O)(O)=O.CS(=O)(O)=O

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for INCB 3284 dimesylate

溶剂 最高浓度 mg/mL 最高浓度 mM
溶解性
water 71.28 100
DMSO 71.28 100

制备储备液 for INCB 3284 dimesylate

以下数据基于产品分子量 712.76。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

选择批次从而根据批次分子量重新计算:
浓度/溶剂体积/质量 1 mg 5 mg 10 mg
1 mM 1.4 mL 7.01 mL 14.03 mL
5 mM 0.28 mL 1.4 mL 2.81 mL
10 mM 0.14 mL 0.7 mL 1.4 mL
50 mM 0.03 mL 0.14 mL 0.28 mL

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产品说明书 for INCB 3284 dimesylate

分析证书/产品说明书
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化学品安全技术说明书

参考文献 for INCB 3284 dimesylate

参考文献是支持产品生物活性的出版物。

Xue et al (2011) Discovery of INCB3284, a potent, selective, and orally bioavailable hCCR2 antagonist. ACS.Med.Chem.Lett. 2 450 PMID: 24900329

If you know of a relevant reference for INCB 3284 dimesylate, please let us know.

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关键词: INCB 3284 dimesylate, INCB 3284 dimesylate supplier, INCB3284, CCR2, antagonist, antagonists, hCCR2, human, chemokine, receptor, receptors, Chemokine, CC, Receptors, 4306, Tocris Bioscience

3 篇 INCB 3284 dimesylate 的引用文献

引用文献是使用了 Tocris 产品的出版物。 INCB 3284 dimesylate 的部分引用包括：

Liu et al (2016) Cancer-associated fibroblasts promote hepatocellular carcinoma metastasis through chemokine-activated hedgehog and TGF-β pathways. Cancer Lett. 379 49 PMID: 27216982

Zhou et al (2015) Klotho gene deficiency causes salt-sensitive hypertension via monocyte chemotactic protein-1/CC chemokine receptor 2-mediated inflammation. Nat Commun 26 121 PMID: 24904083

McMillin et al (2014) Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation 11 121 PMID: 25012628

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