Indatraline hydrochloride

Cat. No. 1588 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent 5-HT uptake inhibitor; also inhibits dopamine and noradrenalin uptake

别名： Lu 19-005

化学名： (1R,3S)-rel-3-(3,4-Dichlorophenyl)-2,3-dihydro-N-methyl-1H-inden-1-amine hydrochloride

纯度： ≥99% (HPLC)

文献 (1)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Indatraline hydrochloride

Indatraline hydrochloride is a potent monoamine uptake inhibitor. Inhibits transporters for 5-HT (SERT), dopamine (DAT) and noradrenaline (NET) (K_i values are 0.42, 1.7 and 5.8 nM respectively). Centrally active following systemic administration in vivo.

化合物库 for Indatraline hydrochloride

Indatraline hydrochloride is also offered as part of the Tocriscreen 2.0 Max. 了解 Tocris 化合物库的更多信息。

技术数据 for Indatraline hydrochloride

分子量	328.67
公式	C₁₆H₁₅Cl₂N.HCl
储存	Desiccate at RT
纯度	≥99% (HPLC)
CAS Number	96850-13-4
PubChem ID	10314472
InChI Key	QICQDZXGZOVTEF-MELYUZJYSA-N
Smiles	ClC(C=C3)=C(Cl)C=[C@@]3[C@H]2C1=CC=CC=C1[C@H](NC)C2.Cl

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Indatraline hydrochloride

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	water	3.29	10 温和加热
	DMSO	32.87	100

制备储备液 for Indatraline hydrochloride

以下数据基于产品分子量 328.67。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	3.04 mL	15.21 mL	30.43 mL
5 mM	0.61 mL	3.04 mL	6.09 mL
10 mM	0.3 mL	1.52 mL	3.04 mL
50 mM	0.06 mL	0.3 mL	0.61 mL

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产品说明书 for Indatraline hydrochloride

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Indatraline hydrochloride

参考文献是支持产品生物活性的出版物。

Gu et al (2000) Design, synthesis, and monoamine transporter binding site affinities of methoxy derivatives of indatraline. J.Med.Chem. 43 4868 PMID: 11123996

Hyttel and Larsen (1985) Neurochemical profile of Lu 19-005, a potent inhibitor of uptake of DA, noradrenaline and serotonin. J.Neurochem. 44 1615 PMID: 2580950

Negus et al (1999) Effects of the long-acting monoamine reuptake inhibitor indatraline on cocaine self-administration in rhesus monkeys. J.Pharmacol.Exp.Ther. 291 60 PMID: 10490887

If you know of a relevant reference for Indatraline hydrochloride, please let us know.

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