Indinavir sulfate

Cat. No. 7196 提交评论说明书 / 分析证书（CoA） / 化学品安全技术说明书（SDS）

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说明： Potent and selective HIV-1 and HIV-2 protease inhibitor

化学名： 2,3,5-Trideoxy-N-[(1S,2R)-2,3-dihydro-2-hydroxy-1H-inden-1-yl]-5-[(2S)-2-[[(1,1-dimethylethyl)amino]carbonyl]-4-(3-pyridinylmethyl)-1-piperazinyl]-2-(phenylmethyl)-D-erythro-pentonamide sulfate

纯度： ≥98% (HPLC)

生物活性技术数据溶解性计算器说明书参考文献

生物活性 for Indinavir sulfate

Indinavir sulfate is a potent and selective HIV protease inhibitor (K_i values are 0.52 and 3.3 nM for HIV-1 and HIV-2, respectively). Indinavir stops the spread of the HIV-infected MT4 lymphoid cells at concentrations of 25-50 nM. Indinavir disrupts the ERK1/2 and p38 MAPK pathways and reduces both the level of functional eIF4F complex and rpS6 phosphorylation, which leads to a decrease in protein synthesis in mouse myocytes. In silico docking models predict potential as an inhibitor of SARS-CoV-2 3CL^pro.

技术数据 for Indinavir sulfate

分子量	711.88
公式	C₃₆H₄₇N₅O₄.H₂SO₄
储存	Store at -20°C
纯度	≥98% (HPLC)
CAS Number	157810-81-6
PubChem ID	5462355
InChI Key	NUBQKPWHXMGDLP-BDEHJDMKSA-N
Smiles	S(=O)(=O)(O)O.N(C([C@H](CC1=CC=CC=C1)C[C@@H](CN2[C@H](C(NC(C)(C)C)=O)CN(CC=3C=CC=NC3)CC2)O)=O)[C@H]4C=5C(C[C@H]4O)=CC=CC5

上方提供的技术数据仅供参考。批次相关数据请参见分析证书。

Tocris products are intended for laboratory research use only, unless stated otherwise.

溶解性数据 for Indinavir sulfate

	溶剂	最高浓度 mg/mL	最高浓度 mM
溶解性
	DMSO	71.19	100
	water	71.19	100

制备储备液 for Indinavir sulfate

以下数据基于产品分子量 711.88。 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

浓度/溶剂体积/质量	1 mg	5 mg	10 mg
1 mM	1.4 mL	7.02 mL	14.05 mL
5 mM	0.28 mL	1.4 mL	2.81 mL
10 mM	0.14 mL	0.7 mL	1.4 mL
50 mM	0.03 mL	0.14 mL	0.28 mL

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产品说明书 for Indinavir sulfate

分析证书/产品说明书

化学品安全技术说明书

参考文献 for Indinavir sulfate

参考文献是支持产品生物活性的出版物。

Dorsey et al (1994) L-735,524: the design of a potent and orally bioavailable HIV protease inhibitor. J.Med.Chem. 37 3443 PMID: 7932573

Brown et al (2004) Indinavir impairs protein synthesis and phosphorylations of MAPKs in mouse C₂C₁₂ myocytes. Am.J.Physiol.Cell Physiol. 287 C1482-92 PMID: 15229102

Brown et al (2005) Indinavir alters regulators of protein anabolism and catabolism in skeletal muscle. Am.J.Physiol.Endocrinol.Metab. 289 E382-90 PMID: 15827064

Hall et al (2020) A search for medications to treat COVID-19 via in silico molecular docking models of the SARS-CoV-2 spike glycoprotein and 3CL protease. Travel Med.Infect.Dis. 35 101646 PMID: 32294562

If you know of a relevant reference for Indinavir sulfate, please let us know.

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